Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | TP53 | P04637 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19714481 | 0.90 | SMN1; SMN2 (0.60) | MAPTTP53SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL17824307 | 0.88 | SMN1; SMN2 (0.58) | MAPTTP53SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL27898285 | 0.83 | ALDH1A1 (0.83) | MAPTTP53SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL27898226 | 0.80 | CYP1A2 (0.68) | MAPTTP53SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL17824285 | 0.79 | DRD2 (0.52) | MAPTTP53SMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL19714188 | 0.79 | RAB9A (0.61) | MAPTTP53SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL19714271 | 0.79 | CYP1A2 (0.59) | MAPTTP53SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL17824299 | 0.77 | RAB9A (0.53) | MAPTTP53SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL17824312 | 0.76 | RAB9A (0.64) | MAPTTP53SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL1170660 | 0.76 | ALDH1A1 (0.86) | MAPTSMN1; SMN2ALDH1A1L3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016092327-A1 | PRO-SURVIVAL COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW (GB) | 2016-06-16 | — | — | WO | disclosed |