Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17824307 | 0.86 | SMN1; SMN2 (0.58) | CYP1A2CYP3A4CYP2D6CYP2C19MAPT | |
| SCHEMBL19714481 | 0.85 | SMN1; SMN2 (0.60) | CYP1A2CYP3A4CYP2D6CYP2C19MAPT | |
| SCHEMBL27898226 | 0.83 | CYP1A2 (0.68) | CYP1A2CYP3A4CYP2D6CYP2C19MAPT | |
| SCHEMBL1170660 | 0.79 | ALDH1A1 (0.86) | CYP1A2CYP3A4CYP2D6CYP2C19MAPT | |
| SCHEMBL17833378 | 0.79 | MAPT (0.65) | CYP1A2CYP3A4CYP2D6CYP2C19MAPT | |
| SCHEMBL27898285 | 0.78 | ALDH1A1 (0.83) | CYP1A2CYP3A4CYP2D6CYP2C19MAPT | |
| SCHEMBL6030662 | 0.76 | KDM4E (0.52) | CYP1A2CYP3A4CYP2D6CYP2C19MAPT | |
| SCHEMBL6029552 | 0.75 | KMT2A (0.53) | MAPTALDH1A1TP53SMN1; SMN2LMNA | |
| SCHEMBL19713871 | 0.74 | CYP1A2 (0.63) | CYP1A2CYP3A4CYP2D6CYP2C19MAPT | |
| SCHEMBL27915822 | 0.73 | ALDH1A1 (0.76) | CYP1A2CYP3A4CYP2D6CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362184-A1 | PRO-SURVIVAL COMPOUNDS | HERIOT-WATT UNIVERSITY (GB) | 2017-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362184-A1 | PRO-SURVIVAL COMPOUNDS | MCL1, MKI67, MORF4L1 | CYP1A2 4708/4885CYP3A4 4779/4885CYP2D6 4681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.