Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | IL1B | P01584 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7896269 | 0.83 | SLC6A3 (0.71) | SLC6A3SLC6A4SLC6A2P2RX7KDM1A | |
| SCHEMBL14893528 | 0.83 | P2RX7 (0.50) | SLC6A3SLC6A4SLC6A2P2RX7OPRM1 | |
| SCHEMBL21134568 | 0.83 | SLC6A3 (0.46) | SLC6A3SLC6A4SLC6A2P2RX7OPRM1 | |
| SCHEMBL12614285 | 0.81 | SLC6A3 (0.45) | SLC6A3SLC6A4SLC6A2P2RX7OPRM1 | |
| SCHEMBL29017393 | 0.78 | SLC6A3 (0.46) | SLC6A3SLC6A4SLC6A2P2RX7OPRM1 | |
| SCHEMBL29017368 | 0.78 | SLC6A3 (0.46) | SLC6A3SLC6A4SLC6A2P2RX7OPRM1 | |
| SCHEMBL14513169 | 0.77 | ALDH1A1 (0.50) | SLC6A3SLC6A4SLC6A2MAOAMAOB | |
| SCHEMBL31525724 | 0.75 | ALDH1A1 (0.54) | — | |
| SCHEMBL24397813 | 0.74 | OPRL1 (0.49) | SLC6A3SLC6A4SLC6A2P2RX7OPRM1 | |
| SCHEMBL18717557 | 0.74 | MAOA (0.46) | SLC6A3SLC6A4SLC6A2P2RX7OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160168090-A1 | NOVEL INDOLE DERIVATIVES AND THEIR USE IN NEURODEGENERATIVE DISEASES | MERCK PATENT GMBH (DE) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168090-A1 | NOVEL INDOLE DERIVATIVES AND THEIR USE IN NEURODEGENERATIVE DISEASES | P2RX3, P2RX7, P2RX2 | SLC6A3 59/4885SLC6A4 43/4885SLC6A2 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.