Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27619766 | 0.84 | SLC6A3 (0.61) | SIGMAR1HRH3SLC6A3 | |
| SCHEMBL16416933 | 0.84 | ALDH1A1 (0.47) | HRH3 | |
| SCHEMBL16345749 | 0.81 | SIGMAR1 (0.45) | SIGMAR1L3MBTL3HRH3L3MBTL1MBTD1 | |
| SCHEMBL1241103 | 0.78 | HRH3 (0.68) | SIGMAR1L3MBTL3HRH3L3MBTL1MBTD1 | |
| SCHEMBL4960414 | 0.78 | HRH3 (0.62) | SIGMAR1L3MBTL3HRH3L3MBTL1MBTD1 | |
| SCHEMBL6627983 | 0.77 | HRH3 (0.71) | SIGMAR1L3MBTL3HRH3L3MBTL1MBTD1 | |
| SCHEMBL16670770 | 0.75 | SIGMAR1 (0.49) | SIGMAR1L3MBTL3HRH3TDP1 | |
| SCHEMBL16676687 | 0.75 | L3MBTL3 (0.43) | SIGMAR1L3MBTL3HRH3L3MBTL1MBTD1 | |
| SCHEMBL18069850 | 0.75 | HRH3 (0.57) | SIGMAR1L3MBTL3HRH3 | |
| SCHEMBL2730391 | 0.74 | SIGMAR1 (0.57) | SIGMAR1L3MBTL3HRH3L3MBTL1MBTD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10414754-B2 | Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2019-09-17 | — | — | US | disclosed |
| US-20180186771-A1 | INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2018-07-05 | — | — | US | disclosed |
| US-9944620-B2 | Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2018-04-17 | — | — | US | disclosed |
| CN-105579450-B | Novel indolizine compounds, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2017-12-12 | — | — | CN | disclosed |
| EP-3024833-B1 | NOVEL INDOLIZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2017-09-06 | — | — | EP | disclosed |
| US-20160176848-A1 | INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2016-06-23 | — | — | US | disclosed |
| CN-105579450-A | Novel indolizine compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB | 2016-05-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180186771-A1 | INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | IDO1, API5, IDO2 | SIGMAR1 2778/4885L3MBTL3 3030/4885HRH3 31/4885 |
| US-10414754-B2 | Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them | IDO1, API5, IDO2 | SIGMAR1 2778/4885L3MBTL3 3030/4885HRH3 31/4885 |
| US-20160176848-A1 | INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | IDO1, API5, IDO2 | SIGMAR1 2778/4885L3MBTL3 3030/4885HRH3 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.