Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29088666 | 0.82 | ALDH1A1 (0.49) | LMNAHTTACHEHIF1ACA1 | |
| SCHEMBL14892302 | 0.81 | APP (0.54) | LMNAHTTMAPK1RAB9AACHE | |
| SCHEMBL22772337 | 0.81 | SHBG (0.44) | LMNAHTTHIF1ACA1CA2 | |
| SCHEMBL26861544 | 0.81 | LMNA (0.44) | LMNAHTTMAPK1RAB9AFFAR1 | |
| SCHEMBL31349241 | 0.80 | BLM (0.56) | HTTRAB9AKMT2ANPSR1 | |
| SCHEMBL22723277 | 0.78 | ADRB1 (0.43) | LMNAARHIF1ACA1CA2 | |
| SCHEMBL22723275 | 0.78 | ADRB1 (0.43) | LMNAARHIF1ACA1CA2 | |
| SCHEMBL22723271 | 0.77 | SMN1; SMN2 (0.38) | HIF1AGRM2GRM3 | |
| SCHEMBL22723270 | 0.77 | SMN1; SMN2 (0.38) | HIF1AGRM2GRM3 | |
| SCHEMBL29194850 | 0.77 | HIF1A (0.40) | ACHEHIF1ACA1CA2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016095088-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |