Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.40 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.40 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.40 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5657055 | 0.76 | MCL1 (0.37) | LMNATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5606955 | 0.72 | L3MBTL1 (0.42) | LMNAMAPTL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL8610000 | 0.69 | CTSV (0.53) | LMNAMAPTALDH1A1KDM4EHTT | |
| SCHEMBL19949651 | 0.69 | TRPM8 (0.52) | LMNAMAPTALDH1A1KDM4EHTT | |
| SCHEMBL9017495 | 0.69 | PPARG (0.46) | MAPK14MAPK13MAPK12MAPK11TUBB4A | |
| SCHEMBL4144103 | 0.67 | CTSV (0.47) | LMNAMAPTALDH1A1KDM4EHTT | |
| SCHEMBL5690733 | 0.66 | PTGER1 (0.53) | PTGER1ALDH1A1SLC6A4MEN1KMT2A | |
| SCHEMBL4156570 | 0.66 | CTSV (0.55) | LMNAMAPTALDH1A1KDM4EHTT | |
| SCHEMBL437304 | 0.65 | PTGS1 (0.39) | LMNAMAPK14MAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL436260 | 0.65 | PTGS1 (0.38) | LMNAMAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233828-A1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | F. Hoffmann-La Roche AG (CH) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097071-A1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2016-06-23 | — | — | WO | disclosed |