SCHEMBL17845686

SCHEMBL17845686

Clc1cccc(NC2CCO[CH]C2Cl)c1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
FADS1 O60427 1/20 0.43
LMNA P02545 5/20 0.40
HTT P42858 2/20 0.39
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C19 P33261 1/20 0.39
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
EPHX2 P34913 2/20 0.36
EPHX1 P07099 1/20 0.36
TSHR P16473 1/20 0.36
POLB P06746 1/20 0.36
ALDH1A1 P00352 2/20 0.36
MAPT P10636 2/20 0.36
IDO1 P14902 1/20 0.36
MAPK1 P28482 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17845543 0.85 DDB1 (0.39) LMNAHTTMEN1KMT2ACYP3A4
SCHEMBL17845599 0.84 MEN1 (0.33) MEN1KMT2AMAPT
SCHEMBL17845655 0.84 TSHR (0.37) LMNAMEN1KMT2ACYP1A2CYP3A4
SCHEMBL17845596 0.84 KDM4E (0.41) HTTMEN1KMT2ANPC1RAB9A
SCHEMBL17845626 0.84 FADS1 (0.42) FADS1LMNAHTTMEN1KMT2A
SCHEMBL17845512 0.84 FADS1 (0.42) FADS1LMNAHTTMEN1KMT2A
SCHEMBL17845760 0.83 ALDH1A1 (0.40) LMNAALDH1A1
SCHEMBL17845622 0.81 SMN1; SMN2 (0.40) LMNAHTTNPC1RAB9APOLB
SCHEMBL17845537 0.81 RAB9A (0.43) LMNAHTTMEN1KMT2ANPC1
SCHEMBL17845768 0.78 HTT (0.38) LMNAHTTMEN1KMT2ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3233860-A1 SUBSTITUTED 6-ANILINO-9-HETEROCYCLYLPURINE DERIVATIVES FOR INHIBITION OF PLANT STRESS Univerzita Palackého V Olomouci (CZ) 2017-10-25 EP disclosed
WO-2016095881-A1 SUBSTITUTED 6-ANILINO-9-HETEROCYCLYLPURINE DERIVATIVES FOR INHIBITION OF PLANT STRESS UNIVERZITA PALACKEHO V OLOMOUCI (CZ) 2016-06-23 WO disclosed