Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27165476 | 0.92 | ALDH1A1 (0.38) | MEN1KMT2AKDM4EUSP2ALDH1A1 | |
| SCHEMBL13655626 | 0.84 | ATM (0.45) | MEN1KMT2AALDH1A1HPGDTDP1 | |
| SCHEMBL18803167 | 0.83 | GAA (0.42) | KMT2ATDP1JAK2JAK1GAA | |
| SCHEMBL28395559 | 0.82 | ATM (0.43) | MEN1KMT2AALDH1A1LMNAHPGD | |
| SCHEMBL29969222 | 0.79 | CA2 (0.39) | KMT2AJAK2JAK1GAAUCHL1 | |
| SCHEMBL13655637 | 0.79 | L3MBTL1 (0.48) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL17848849 | 0.79 | JAK2 (0.33) | JAK2JAK1 | |
| SCHEMBL19121772 | 0.78 | POLB (0.35) | MEN1KMT2AKDM4EUSP2ALDH1A1 | |
| SCHEMBL15832603 | 0.77 | ALDH1A1 (0.53) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL17820875 | 0.75 | USP2 (0.45) | MEN1KMT2AUSP2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233863-A1 | FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS | CMG Pharmaceutical Co., Ltd. (KR) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097869-A1 | FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS | CMG PHARMACEUTICAL CO., LTD. (KR) | 2016-06-23 | — | — | WO | disclosed |