Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848825 | 0.92 | MEN1 (0.33) | ALDH1A1HSD17B10KDM4EMEN1USP2 | |
| SCHEMBL13655626 | 0.91 | ATM (0.45) | ALDH1A1MEN1HPGDKMT2ATDP1 | |
| SCHEMBL18803167 | 0.90 | GAA (0.42) | KMT2ATDP1GAAJAK2JAK1 | |
| SCHEMBL28395559 | 0.90 | ATM (0.43) | ALDH1A1HSD17B10MEN1LMNAHPGD | |
| SCHEMBL13655637 | 0.86 | L3MBTL1 (0.48) | ALDH1A1HSD17B10KDM4EMEN1LMNA | |
| SCHEMBL29969222 | 0.86 | CA2 (0.39) | KMT2AGAAJAK2JAK1UCHL1 | |
| SCHEMBL17848849 | 0.86 | JAK2 (0.33) | JAK2JAK1 | |
| SCHEMBL19121772 | 0.84 | POLB (0.35) | ALDH1A1HSD17B10KDM4EMEN1USP2 | |
| SCHEMBL15832603 | 0.83 | ALDH1A1 (0.53) | ALDH1A1KDM4EMEN1LMNAHPGD | |
| SCHEMBL17820875 | 0.82 | USP2 (0.45) | MEN1USP2HPGDKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024046929-A1 | A METHOD OF MODIFYING AN ORGANIC CYTOTOXIN FOR USE AS A PAYLOAD IN AN ANTIBODY-DRUG CONJUGATE AND MODIFIED ORGANIC CYTOTOXINS DERIVED THEREFROM | SIMRIS BIOLOGICS GMBH (DE) | 2024-03-07 | — | — | WO | disclosed |