Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 8/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 8/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.40 |
| ▸ | FABP2 | P12104 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22443166 | 0.89 | PTGS2 (0.41) | PTGS2AKR1C3AKR1C2PTGS1CYP2C19 | |
| SCHEMBL28915928 | 0.80 | AKR1C3 (0.40) | PTGS2AKR1C3AKR1C2PTGS1CYP2C19 | |
| SCHEMBL16207444 | 0.79 | PTGS1 (0.36) | PTGS2PTGS1MEN1KMT2APSEN1 | |
| SCHEMBL1000705 | 0.79 | KDM4E (0.44) | PTGS2AKR1C3AKR1C2PTGS1MEN1 | |
| SCHEMBL17284101 | 0.77 | PTGS2 (0.54) | PTGS2AKR1C3AKR1C2PTGS1CYP2C19 | |
| SCHEMBL15645912 | 0.75 | CES2 (0.47) | PTGS2AKR1C3AKR1C2PTGS1CYP2C19 | |
| SCHEMBL15645990 | 0.75 | CES2 (0.47) | PTGS2AKR1C3AKR1C2PTGS1CYP2C19 | |
| SCHEMBL20993114 | 0.75 | AKR1C3 (0.42) | PTGS2AKR1C3AKR1C2PTGS1CYP2C19 | |
| SCHEMBL16207437 | 0.74 | AKR1C3 (0.49) | AKR1C3AKR1C2MEN1KMT2ACYP2C9 | |
| SCHEMBL29009979 | 0.73 | AKR1C3 (0.42) | PTGS2AKR1C3AKR1C2PTGS1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102459283-B | Aminopyrazole triazolothiadiazole inhibitors of C-MET protein kinase | VERTEX PHARMA | 2014-11-12 | — | — | CN | disclosed |
| EP-2435443-B1 | AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTIEN KINASE | VERTEX PHARMA (US) | 2013-07-31 | — | — | EP | disclosed |
| EP-2435443-B1 | AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTIEN KINASE | VERTEX PHARMA (US) | 2013-07-31 | — | — | EP | disclosed |
| US-20130018072-A1 | AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-17 | — | — | US | disclosed |
| US-20130018072-A1 | AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-17 | — | — | US | disclosed |
| US-20130018072-A1 | AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-17 | — | — | US | disclosed |
| US-8269012-B2 | Aminopyrazole triazolothiadiazole inhibitors of c-met protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-09-18 | — | — | US | disclosed |
| US-8269012-B2 | Aminopyrazole triazolothiadiazole inhibitors of c-met protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-09-18 | — | — | US | disclosed |
| US-8269012-B2 | Aminopyrazole triazolothiadiazole inhibitors of c-met protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-09-18 | — | — | US | disclosed |
| US-8269013-B2 | Substituted pyrazole inhibitors of c-Met protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-09-18 | — | — | US | disclosed |
| US-20110124684-A1 | AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTIEN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-05-26 | — | — | US | disclosed |
| WO-2010138673-A1 | INHIBITORS OF C-MET PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010138663-A1 | SUBSTITUTED PYRAZOLE INHIBITORS OF C-MET PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010138663-A1 | SUBSTITUTED PYRAZOLE INHIBITORS OF C-MET PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010138665-A1 | AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTIEN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010138665-A1 | AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTIEN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010138673-A1 | INHIBITORS OF C-MET PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-02 | — | — | WO | disclosed |
| US-20100305156-A1 | INHIBITORS OF C-MET PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100305155-A1 | SUBSTITUTED PYRAZOLE INHIBITORS OF C-MET PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100305156-A1 | INHIBITORS OF C-MET PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305155-A1 | SUBSTITUTED PYRAZOLE INHIBITORS OF C-MET PROTEIN KINASE | MET, BRAF, DMPK | PTGS2 2782/4885AKR1C3 2293/4885AKR1C2 2870/4885 |
| US-20100305156-A1 | INHIBITORS OF C-MET PROTEIN KINASE | MET, BRAF, HGF | PTGS2 2351/4885AKR1C3 2192/4885AKR1C2 2577/4885 |
| US-20110124684-A1 | AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTIEN KINASE | MET, MELK, DMPK | PTGS2 735/4885AKR1C3 2500/4885AKR1C2 3124/4885 |
| US-20130018072-A1 | AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTEIN KINASE | MET, ABL1, DMPK | PTGS2 1599/4885AKR1C3 2470/4885AKR1C2 2888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.