Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | VNN1 | O95497 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.30 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17853170 | 0.82 | KDM4C (0.42) | LPAR1VNN1KDM4CALDH1A1NR3C1 | |
| SCHEMBL4204205 | 0.80 | ALDH1A1 (0.41) | LPAR1VNN1KDM4CALDH1A1KMT2A | |
| SCHEMBL19730080 | 0.78 | GABRA1 (0.33) | GABRA1KMT2A | |
| SCHEMBL27661737 | 0.78 | VNN1 (0.34) | LPAR1VNN1KDM4CALDH1A1KMT2A | |
| SCHEMBL17853169 | 0.75 | ALDH1A1 (0.51) | ALDH1A1KMT2AKDM4E | |
| SCHEMBL6065942 | 0.74 | VNN1 (0.34) | LPAR1VNN1KDM4CALDH1A1NR3C1 | |
| SCHEMBL3119092 | 0.72 | LPAR1 (0.38) | LPAR1VNN1KDM4CALDH1A1KMT2A | |
| SCHEMBL4206941 | 0.71 | HTT (0.41) | ALDH1A1KMT2ANR3C1KDM4E | |
| SCHEMBL6065837 | 0.71 | LPAR1 (0.37) | LPAR1VNN1KDM4CALDH1A1KMT2A | |
| SCHEMBL6425412 | 0.71 | ALDH1A1 (0.37) | LPAR1VNN1ALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10035774-B2 | Pyrazolyl carboxylic acid and pyrazolyl urea derivative compounds | MERCK SHARP & DOHME CORP. (US) | 2018-07-31 | — | — | US | disclosed |
| US-10035774-B2 | Pyrazolyl carboxylic acid and pyrazolyl urea derivative compounds | MERCK SHARP & DOHME CORP. (US) | 2018-07-31 | — | — | US | disclosed |
| US-20170362183-A1 | PYRAZOLYL CARBOXYLIC ACID AND PYRAZOLYL UREA DERIVATIVE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2017-12-21 | — | — | US | disclosed |
| US-20170362183-A1 | PYRAZOLYL CARBOXYLIC ACID AND PYRAZOLYL UREA DERIVATIVE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2017-12-21 | — | — | US | disclosed |
| WO-2016095860-A1 | PYRAZOLYL CARBOXYLIC ACID AND PYRAZOLYL UREA DERIVATIVE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362183-A1 | PYRAZOLYL CARBOXYLIC ACID AND PYRAZOLYL UREA DERIVATIVE COMPOUNDS | UROD, PEPD, CMPK1 | GABRA1 1252/4885LPAR1 4862/4885VNN1 2196/4885 |
| US-10035774-B2 | Pyrazolyl carboxylic acid and pyrazolyl urea derivative compounds | UROD, PEPD, CMPK1 | GABRA1 1252/4885LPAR1 4862/4885VNN1 2196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.