Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.60 |
| ▸ | CA2 | P00918 | 2/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3657271 | 0.98 | ACHE (0.58) | ACHECA2CA1CYP2D6HPGD | |
| SCHEMBL17113704 | 0.85 | CYP2D6 (0.46) | ACHECA2CA1CYP2D6HPGD | |
| SCHEMBL14318777 | 0.85 | CYP2D6 (0.50) | ACHECA2CA1CYP2D6HPGD | |
| Hydrochloric Acid SCHEMBL5774500 | 0.84 | ACHE (0.60) | ACHECA2CA1HPGDKDM1A | |
| SCHEMBL19790002 | 0.84 | KDM4E (0.47) | ACHECA2CA1CYP2D6HPGD | |
| SCHEMBL10189787 | 0.83 | CYP2D6 (0.45) | ACHECA2CA1CYP2D6HPGD | |
| SCHEMBL178499 | 0.83 | CYP2D6 (0.49) | ACHECA2CA1CYP2D6HPGD | |
| SCHEMBL2668984 | 0.83 | TAS1R3 (0.49) | ACHECA2CA1CYP2D6ALDH1A1 | |
| SCHEMBL9781293 | 0.82 | ACHE (0.58) | ACHECA2CA1HPGDKDM1A | |
| SCHEMBL12870325 | 0.82 | ACHE (0.58) | ACHECA2CA1HPGDKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222629-A1 | PROCESS FOR PREPARING N-METHYL-3, 4 DIMETHOXYPHENYLETHYLAMINE | Sicor, Inc. (US) | 2010-09-01 | — | — | EP | claimed |
| WO-2009086464-A1 | PROCESS FOR PREPARING N-METHYL-3, 4 DIMETHOXYPHENYLETHYLAMINE | SICOR INC. (US) | 2009-07-09 | — | — | WO | claimed |
| US-20090171110-A1 | PROCESS FOR PREPARING N-METHYL-3, 4-DIMETHOXYPHENYLETHYLAMINE | SICOR INC. | 2009-07-02 | — | — | US | claimed |
| EP-0389876-B1 | NEW PROCESS FOR THE SYNTHESIS OF THE N-METHYL-3,4-DIMETHOXYPHENYLETHYLAMINE | Alfa Chemicals Italiana S.r.l. (IT) | 1993-08-04 | — | — | EP | claimed |
| US-5057624-A | PROCESS FOR THE SYNTHESIS OF THE N-METHYL-3,4-DIMETHOXYPHENYLETHYLAMINE | ALFA WASSERMANN S.P.A. (IT) | 1991-10-15 | — | — | US | claimed |
| EP-0389876-A1 | New process for the synthesis of the N-methyl-3,4-dimethoxyphenylethylamine | Alfa Chemicals Italiana S.r.l. (IT) | 1990-10-03 | — | — | EP | claimed |
| US-8883824-B2 | 3-(4-aminophenyl)-2-furancarboxylic acid derivative and pharmaceutically acceptable salt thereof | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2014-11-11 | — | — | US | disclosed |
| US-20130059844-A1 | 2-PHENYL SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2013-03-07 | — | — | US | disclosed |
| US-20120059012-A1 | 3-(4-AMINOPHENYL)-2-FURANCARBOXYLIC ACID DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-03-08 | — | — | US | disclosed |
| EP-2295436-A1 | 2-Phenyl-subsitituted Imidazotriazinones as Phosphodiesterase V inhibitors | Bayer Schering Pharma AG (DE) | 2011-03-16 | — | — | EP | disclosed |
| US-20110009367-A1 | 2-PHENYL SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-01-13 | — | — | US | disclosed |
| EP-2222629-A1 | PROCESS FOR PREPARING N-METHYL-3, 4 DIMETHOXYPHENYLETHYLAMINE | Sicor, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| US-7704999-B2 | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-04-27 | — | — | US | disclosed |
| US-4833162-A | Substituted benzeneacetonitriles and their use as calcium channel blockers | AMERICAN CYANAMID COMPANY (US) | 1989-05-23 | — | — | US | disclosed |
| US-4723039-A | CARDIOVASCULAR DISORDERS; ULCERS | BASF AKTIENGESELLSCHAFT (DE) | 1988-02-02 | — | — | US | disclosed |
| CN-85101312-A | Process for preparing Benzothiazine derivatives | — | 1987-04-08 | — | — | CN | disclosed |
| US-4137318-A | HYPOTENSIVES AND HEART RATE REDUCERS | BOEHRINGER INGELHEIM GMBH (DE) | 1979-01-30 | — | — | US | disclosed |
| US-4134980-A | Phenylalkylamino-alkyl derivatives of quinazolinone and phthalazinone | BOEHRINGER INGELHEIM GMBH (DE) | 1979-01-16 | — | — | US | disclosed |
| US-4087541-A | REDUCING HEART RATE | BOEHRINGER INGELHEIM GMBH (DT) | 1978-05-02 | — | — | US | disclosed |
| US-4038407-A | HEART RATE SLOWING DRUGS | BOEHRINGER INGELHEIM GMBH (DT) | 1977-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090171110-A1 | PROCESS FOR PREPARING N-METHYL-3, 4-DIMETHOXYPHENYLETHYLAMINE | PNMT, COMT, TET3 | ACHE 425/4885CA2 2920/4885CA1 4460/4885 |
| US-20110009367-A1 | 2-PHENYL SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS | PDE3B, PDE3A, PDE2A | ACHE 203/4885CA2 1494/4885CA1 4584/4885 |
| US-20130059844-A1 | 2-PHENYL SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS | PDE3B, PDE3A, PDE2A | ACHE 203/4885CA2 1494/4885CA1 4584/4885 |
| US-20120059012-A1 | 3-(4-AMINOPHENYL)-2-FURANCARBOXYLIC ACID DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | ACSL3, SLCO4C1, SLC38A7 | ACHE 3347/4885CA2 314/4885CA1 895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.