Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 2/20 | 0.47 |
| ▸ | PLCG1 | P19174 | 4/20 | 0.43 |
| ▸ | PLCB3 | Q01970 | 4/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860329 | 0.88 | CASP6 (0.60) | CASP6PLCG1PLCB3PAX8CHRNB4 | |
| SCHEMBL17860361 | 0.81 | PLCG1 (0.54) | CASP6PLCG1PLCB3PAX8CHRNB4 | |
| SCHEMBL17860390 | 0.72 | PAX8 (0.58) | CASP6PLCG1PLCB3PAX8CHRNB4 | |
| SCHEMBL17860328 | 0.70 | PLCG1 (0.64) | CASP6PLCG1PLCB3PAX8CHRNB4 | |
| SCHEMBL27349441 | 0.64 | HTR1A (0.44) | — | |
| SCHEMBL13311839 | 0.64 | FFAR1 (0.46) | — | |
| SCHEMBL17860392 | 0.62 | PAX8 (0.58) | CASP6PLCG1PLCB3PAX8CHRNB4 | |
| SCHEMBL6554279 | 0.62 | MTNR1A (0.51) | — | |
| SCHEMBL6554163 | 0.62 | MTNR1A (0.51) | — | |
| SCHEMBL6553933 | 0.62 | MTNR1A (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100711-A1 | MODULATORS OF HEPATIC LIPOPROTEIN METABOLISM | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |