Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 15/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.38 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.35 |
| ▸ | NNMT | P40261 | 3/20 | 0.35 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17865948 | 0.81 | PRMT5 (0.44) | PRMT5WDR77METTL3 | |
| SCHEMBL17866033 | 0.79 | PRMT5 (0.44) | PRMT5WDR77SLC29A1 | |
| SCHEMBL192426 | 0.77 | PRMT5 (0.49) | PRMT5WDR77SLC29A1 | |
| SCHEMBL192337 | 0.76 | CA2 (0.49) | PRMT5WDR77METTL3 | |
| SCHEMBL192440 | 0.76 | CA2 (0.49) | PRMT5WDR77METTL3 | |
| SCHEMBL17865966 | 0.73 | SLC29A1 (0.51) | SLC29A1 | |
| SCHEMBL10004855 | 0.69 | ADK (0.47) | — | |
| SCHEMBL17865980 | 0.69 | UBA6 (0.38) | PRMT5WDR77SLC29A1METTL3 | |
| SCHEMBL17865956 | 0.68 | NAE1 (0.43) | PRMT5METTL3 | |
| SCHEMBL17865973 | 0.67 | UBA6 (0.42) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | claimed |