Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL392238 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL17836014 | 0.68 | ALDH1A1 (0.33) | ALDH1A1CA2POLBTYRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL394796 | 0.68 | TSHR (0.31) | CA2 | |
| Hydrochloric Acid SCHEMBL4461086 | 0.67 | CA4 (0.30) | — | |
| Hydrochloric Acid SCHEMBL4359909 | 0.66 | — | — | |
| Hydrochloric Acid SCHEMBL3154711 | 0.66 | ALDH1A1 (0.34) | ALDH1A1CA2POLBTYRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL714251 | 0.65 | GABRA1 (0.33) | CA2 | |
| Hydrochloric Acid SCHEMBL3615425 | 0.65 | MEN1 (0.33) | SMN1; SMN2 | |
| SCHEMBL27800581 | 0.64 | SMN1; SMN2 (0.56) | ALDH1A1CA2POLBTYRSMN1; SMN2 | |
| SCHEMBL2868170 | 0.64 | SMN1; SMN2 (0.50) | ALDH1A1CA2POLBTYRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3034545-B1 | A PROCESS FOR THE PREPARATION OF A GRAFT COPOLYMER COMPRISING A POLYOLEFIN MAIN CHAIN AND ONE OR A MULTIPLE POLYMER SIDE CHAINS AND THE PRODUCTS OBTAINED THEREFROM | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2020-11-04 | — | — | EP | disclosed |
| EP-3037438-A1 | Process for the preparation of a branched polyolefin | SABIC Global Technologies B.V. (NL) | 2016-06-29 | — | — | EP | disclosed |