SCHEMBL178731

SCHEMBL178731

O=C(NNc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21

nearest known ligand 0.57

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.57
EPHX2 P34913 1/20 0.54
GAA P10253 1/20 0.47
FABP5 Q01469 3/20 0.44
FABP7 O15540 2/20 0.44
CASP3 P42574 2/20 0.43
MDM4 O15151 1/20 0.41
TP53 P04637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12235815 0.91 KMT2A (0.64) KMT2AEPHX2GAAFABP5FABP7
SCHEMBL118052 0.87 EPHX2 (0.63) KMT2AEPHX2FABP5FABP7CASP3
SCHEMBL29401210 0.87 EPHX2 (0.63) KMT2AEPHX2FABP5FABP7CASP3
SCHEMBL29561956 0.87 EPHX2 (0.63) KMT2AEPHX2FABP5FABP7CASP3
SCHEMBL13187755 0.86 EPHX2 (0.60) KMT2AEPHX2GAAFABP5FABP7
SCHEMBL14898524 0.86 KMT2A (0.59) KMT2AEPHX2GAAFABP5FABP7
SCHEMBL114404 0.84 KMT2A (0.60) KMT2AEPHX2GAAFABP5FABP7
SCHEMBL7913189 0.84 EPHX2 (0.59) KMT2AEPHX2FABP5FABP7CASP3
SCHEMBL22635803 0.84 KMT2A (0.56) KMT2AEPHX2GAAFABP5CASP3
SCHEMBL346077 0.82 KMT2A (0.52) KMT2AEPHX2GAAFABP5FABP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4247541-B1 METHODS OF MAKING AND USING PLATFORMS FOR PEPTIDE SYNTHESIS AND COMPOSITIONS THEREOF PEPTILOGICS INC (US) 2024-08-28 EP claimed
US-20240002431-A1 METHODS OF MAKING AND USING PLATFORMS FOR PEPTIDE SYNTHESIS AND COMPOSITIONS THEREOF PEPTILOGICS, INC. (US) 2024-01-04 US claimed
EP-4247541-A1 METHODS OF MAKING AND USING PLATFORMS FOR PEPTIDE SYNTHESIS AND COMPOSITIONS THEREOF Peptilogics, Inc. (US) 2023-09-27 EP claimed
WO-2022109456-A1 METHODS OF MAKING AND USING PLATFORMS FOR PEPTIDE SYNTHESIS AND COMPOSITIONS THEREOF LEE FRANCIS (US) 2022-05-27 WO claimed
EP-3728304-B1 SOLID PHASE SYNTHESIS OF ACYLATED PEPTIDES BACHEM HOLDING AG (CH) 2025-02-12 EP disclosed
US-20240344123-A1 METHODS AND APPARATUSES FOR GENERATING PEPTIDES BY SYNTHESIZING A PORTION OF A DESIGN SPACE TO IDENTIFY PEPTIDES HAVING NON-CANONICAL AMINO ACIDS PEPTILOGICS, INC. (US) 2024-10-17 US disclosed
EP-4247541-B1 METHODS OF MAKING AND USING PLATFORMS FOR PEPTIDE SYNTHESIS AND COMPOSITIONS THEREOF PEPTILOGICS INC (US) 2024-08-28 EP disclosed
US-12006541-B2 Methods and apparatuses for generating peptides by synthesizing a portion of a design space to identify peptides having non-canonical amino acids PEPTILOGICS, INC. (US) 2024-06-11 US disclosed
US-20240002431-A1 METHODS OF MAKING AND USING PLATFORMS FOR PEPTIDE SYNTHESIS AND COMPOSITIONS THEREOF PEPTILOGICS, INC. (US) 2024-01-04 US disclosed
US-20240002431-A1 METHODS OF MAKING AND USING PLATFORMS FOR PEPTIDE SYNTHESIS AND COMPOSITIONS THEREOF PEPTILOGICS, INC. (US) 2024-01-04 US disclosed
EP-4247541-A1 METHODS OF MAKING AND USING PLATFORMS FOR PEPTIDE SYNTHESIS AND COMPOSITIONS THEREOF Peptilogics, Inc. (US) 2023-09-27 EP disclosed
EP-4247541-A1 METHODS OF MAKING AND USING PLATFORMS FOR PEPTIDE SYNTHESIS AND COMPOSITIONS THEREOF Peptilogics, Inc. (US) 2023-09-27 EP disclosed
EP-1549667-A1 TUMOR TARGETING AGENTS AND USES THEREOF Karyon OY (FI) 2005-07-06 EP disclosed
US-20040253225-A1 bombesin, derivatives and/or analogues capable of complexing metal ions, radionuclides or optical labels, for use in radiotherapy BRACCO IMAGING S.P.A. (IT) 2004-12-16 US disclosed
WO-2004065407-A2 IMPROVED GASTRIN RELEASING PEPTIDE COMPOUNDS BRACCO IMAGING S.P.A. (IT) 2004-08-05 WO disclosed
WO-2004031221-A9 TUMOR TARGETING AGENTS AND USES THEREOF KARYON OY (FI) 2004-07-08 WO disclosed
WO-2004031221-A1 TUMOR TARGETING AGENTS AND USES THEREOF KARYON OY (FI) 2004-04-15 WO disclosed
WO-2004031218-A1 TUMOR TARGETING AGENTS AND USES THEREOF KARYON OY (FI) 2004-04-15 WO disclosed
WO-2004031219-A1 TUMOR TARGETING AGENTS AND USES THEREOF KARYON OY (FI) 2004-04-15 WO disclosed
WO-2004031220-A1 TUMOR TARGETING AGENTS AND USES THEREOF KARYON OY (FI) 2004-04-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040253225-A1 bombesin, derivatives and/or analogues capable of complexing metal ions, radionuclides or optical labels, for use in radiotherapy GRPR, MLNR, NPBWR1 KMT2A 4045/4885EPHX2 3747/4885GAA 1934/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.