Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 4/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17879503 | 0.92 | AHR (0.39) | AHRALOX5PDK2PGRIDO1 | |
| SCHEMBL18156820 | 0.91 | AHR (0.46) | AHRALOX5PDK2PGR | |
| SCHEMBL16250089 | 0.91 | AHR (0.46) | AHRALOX5PDK2PGR | |
| SCHEMBL18732153 | 0.90 | AHR (0.44) | AHRALOX5PDK2PGRIDO1 | |
| SCHEMBL16491662 | 0.90 | PDK2 (0.40) | AHRALOX5PDK2PGRPRKDC | |
| SCHEMBL16491797 | 0.88 | ALOX5 (0.38) | AHRALOX5PDK2PGRPRKDC | |
| SCHEMBL16491900 | 0.87 | AHR (0.40) | AHRALOX5PDK2PGR | |
| SCHEMBL16491854 | 0.86 | AHR (0.38) | AHRPDK2IDO1PTGES | |
| SCHEMBL17879507 | 0.85 | AHR (0.44) | AHRALOX5PDK2PGRIDO1 | |
| SCHEMBL17879500 | 0.85 | AHR (0.40) | AHRALOX5PDK2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-04-27 | — | — | US | disclosed |
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-04-27 | — | — | US | disclosed |
| US-11545634-B2 | Heterocyclic spiro compounds | MERCK PATENT GMBH (DE) | 2023-01-03 | — | — | US | disclosed |
| EP-3708634-A1 | HETEROCYCLIC SPIRO COMPOUNDS | Merck Patent GmbH (DE) | 2020-09-16 | — | — | EP | disclosed |
| US-10777750-B2 | Heterocyclic spiro compounds | BASF SE (DE) | 2020-09-15 | — | — | US | disclosed |
| US-20200266364-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2020-08-20 | — | — | US | disclosed |
| US-10665790-B2 | Materials for electronic devices | MERCK PATENT GMBH (DE) | 2020-05-26 | — | — | US | disclosed |
| EP-3083880-B1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2020-04-01 | — | — | EP | disclosed |
| US-9978950-B2 | Materials for electronic devices | MERCK PATENT GMBH (DE) | 2018-05-22 | — | — | US | disclosed |
| US-9978950-B2 | Materials for electronic devices | MERCK PATENT GMBH (DE) | 2018-05-22 | — | — | US | disclosed |
| EP-3033405-B1 | MATERIALS FOR ELECTRONIC DEVICES | MERCK PATENT GMBH (DE) | 2018-05-09 | — | — | EP | disclosed |
| US-9837617-B2 | Materials for electronic devices | MERCK PATENT GMBH (DE) | 2017-12-05 | — | — | US | disclosed |
| US-9837617-B2 | Materials for electronic devices | MERCK PATENT GMBH (DE) | 2017-12-05 | — | — | US | disclosed |
| US-20170301865-A1 | MATERIALS FOR ELECTRONIC DEVICES | MERCK PATENT GMBH (DE) | 2017-10-19 | — | — | US | disclosed |
| US-20170301865-A1 | MATERIALS FOR ELECTRONIC DEVICES | MERCK PATENT GMBH (DE) | 2017-10-19 | — | — | US | disclosed |
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
| US-20160190466-A1 | MATERIALS FOR ELECTRONIC DEVICES | MERCK PATENT GMBH (DE) | 2016-06-30 | — | — | US | disclosed |
| US-20160190466-A1 | MATERIALS FOR ELECTRONIC DEVICES | MERCK PATENT GMBH (DE) | 2016-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | AHR 1148/4885ALOX5 3721/4885PDK2 264/4885 |
| US-10665790-B2 | Materials for electronic devices | SDHB, SDHA, ETFB | AHR 2826/4885ALOX5 3759/4885PDK2 178/4885 |
| US-11545634-B2 | Heterocyclic spiro compounds | NES, KCNC1, HCN4 | AHR 1148/4885ALOX5 3721/4885PDK2 264/4885 |
| US-20200266364-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | AHR 1148/4885ALOX5 3721/4885PDK2 264/4885 |
| US-20160190466-A1 | MATERIALS FOR ELECTRONIC DEVICES | SDHB, SDHA, ETFB | AHR 2826/4885ALOX5 3759/4885PDK2 178/4885 |
| US-20170301865-A1 | MATERIALS FOR ELECTRONIC DEVICES | SDHB, SDHA, ETFB | AHR 2826/4885ALOX5 3759/4885PDK2 178/4885 |
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | AHR 1148/4885ALOX5 3721/4885PDK2 264/4885 |
| US-10777750-B2 | Heterocyclic spiro compounds | NES, KCNC1, HCN4 | AHR 1148/4885ALOX5 3721/4885PDK2 264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.