Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | PDIA6 | Q15084 | 1/20 | 0.40 |
| ▸ | HBB | P68871 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16444719 | 0.77 | KDM4E (0.39) | SMN1; SMN2KDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL1621421 | 0.76 | KMT2A (0.45) | KDM4EALDH1A1POLBKMT2AMAPT | |
| SCHEMBL18281771 | 0.75 | KDM4E (0.39) | SMN1; SMN2KDM4EALDH1A1POLBLMNA | |
| SCHEMBL20787870 | 0.75 | ALDH1A1 (0.47) | RAB9ASMN1; SMN2KDM4EALDH1A1POLB | |
| SCHEMBL1785567 | 0.74 | SUCNR1 (0.47) | — | |
| SCHEMBL17728285 | 0.74 | ALDH1A1 (0.47) | SMN1; SMN2KDM4EALDH1A1POLBKMT2A | |
| SCHEMBL3337965 | 0.73 | SMN1; SMN2 (0.55) | NPC1RAB9ASMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL16780791 | 0.73 | L3MBTL1 (0.49) | NPC1KDM4EALDH1A1TDP1POLB | |
| SCHEMBL25405576 | 0.73 | PDIA6 (0.51) | NPC1RAB9ASMN1; SMN2KDM4ETDP1 | |
| SCHEMBL2022963 | 0.73 | SMN1; SMN2 (0.47) | NPC1RAB9ASMN1; SMN2TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110124559-A1 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2011-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124559-A1 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | OPRL1, OPRM1, OPRK1 | NPC1 3467/4885RAB9A 1186/4885SMN1; SMN2 1774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.