Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.30 |
| ▸ | LMNA | P02545 | 3/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TPH1 | P17752 | 1/20 | 0.30 |
| ▸ | TPH2 | Q8IWU9 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17896070 | 0.99 | BRPF1 (0.35) | BRPF1HTTKDM4EALDH1A1LMNA | |
| SCHEMBL17896005 | 0.86 | KDM4E (0.34) | KDM4EALDH1A1LMNAMAPTUSP2 | |
| SCHEMBL17895990 | 0.86 | KDM4E (0.33) | KDM4EALDH1A1MAPTTSHR | |
| SCHEMBL17896121 | 0.86 | LMNA (0.34) | KDM4EALDH1A1LMNAMAPTUSP2 | |
| Hydrochloric Acid SCHEMBL17896011 | 0.85 | KDM4E (0.33) | KDM4EALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL17896027 | 0.85 | ALDH1A1 (0.33) | KDM4EALDH1A1LMNAMAPTUSP2 | |
| SCHEMBL17895780 | 0.85 | LMNA (0.34) | KDM4EALDH1A1LMNAMAPTUSP2 | |
| SCHEMBL17895925 | 0.83 | LMNA (0.33) | KDM4EALDH1A1LMNAMAPTUSP2 | |
| SCHEMBL17896071 | 0.82 | ALDH1A1 (0.34) | KDM4EALDH1A1LMNATSHR | |
| SCHEMBL17896017 | 0.82 | LMNA (0.34) | KDM4EALDH1A1LMNAMAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | claimed |
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |