Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1128629 | 0.81 | POLB (0.42) | GAALMNAMAPTALDH1A1POLB | |
| SCHEMBL21393560 | 0.79 | ALDH1A1 (0.38) | GAALMNAMAPTALDH1A1 | |
| SCHEMBL19103697 | 0.77 | TSHR (0.39) | GAAMAPTPOLBSMN1; SMN2 | |
| SCHEMBL17036729 | 0.72 | ALDH1A1 (0.32) | GAALMNAMAPTALDH1A1 | |
| SCHEMBL10154890 | 0.72 | — | — | |
| SCHEMBL8095041 | 0.71 | ALDH1A1 (0.33) | LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL14489954 | 0.69 | ALDH1A1 (0.35) | LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL27831938 | 0.69 | ALDH1A1 (0.38) | GAALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL10772839 | 0.68 | ALDH1A1 (0.36) | LMNAALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL19115797 | 0.68 | CA2 (0.30) | GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9977024-B2 | Targeted covalent probes and inhibitors of proteins containing redox-sensitive cysteines | THE SCRIPPS RESEARCH INSTITUTE (US) | 2018-05-22 | — | — | US | disclosed |
| US-9977024-B2 | Targeted covalent probes and inhibitors of proteins containing redox-sensitive cysteines | THE SCRIPPS RESEARCH INSTITUTE (US) | 2018-05-22 | — | — | US | disclosed |
| US-20160195532-A1 | Targeted Covalent Probes and Inhibitors of Proteins Containing Redox-Sensitive Cysteines | THE SCRIPPS RESEARCH INSTITUTE | 2016-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160195532-A1 | Targeted Covalent Probes and Inhibitors of Proteins Containing Redox-Sensitive Cysteines | PTMS, RSU1, QSOX1 | GAA 4634/4885LMNA 4645/4885MAPT 4374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.