Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 6/20 | 0.38 |
| ▸ | MMP1 | P03956 | 4/20 | 0.38 |
| ▸ | MMP7 | P09237 | 4/20 | 0.38 |
| ▸ | MMP8 | P22894 | 3/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17899639 | 0.92 | PKM (0.43) | SMN1; SMN2LMNAALDH1A1KMT2AMAPT | |
| SCHEMBL17899694 | 0.89 | PKM (0.48) | SMN1; SMN2ALDH1A1KMT2AMEN1HTT | |
| SCHEMBL17899640 | 0.88 | GAA (0.42) | SMN1; SMN2ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL17897332 | 0.87 | EPHX2 (0.41) | SMN1; SMN2ALDH1A1KMT2AGAA | |
| SCHEMBL17899649 | 0.87 | KMT2A (0.41) | SMN1; SMN2KMT2AMAPTMEN1POLB | |
| SCHEMBL17899697 | 0.87 | LMNA (0.43) | LMNAALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL17899692 | 0.86 | PKM (0.46) | SMN1; SMN2LMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL17899650 | 0.85 | KMT2A (0.46) | LMNAALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL17899628 | 0.85 | EPHX2 (0.44) | SMN1; SMN2ALDH1A1KMT2AMAPTNPC1 | |
| SCHEMBL17899643 | 0.84 | GAA (0.43) | SMN1; SMN2LMNAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016107544-A1 | INTERMEDIATE COMPOUND FOR PREPARING PYRROLE AMIDE COMPOUND AND PREPARATION METHOD AND USE THEREOF | 成都先导药物开发有限公司 | 2016-07-07 | — | — | WO | disclosed |