Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4226841 | 0.85 | PRKDC (0.33) | PRKDCKDM4EALDH1A1 | |
| SCHEMBL12610512 | 0.78 | HSD17B1 (0.34) | PRKDC | |
| SCHEMBL13219241 | 0.78 | HRH3 (0.33) | — | |
| SCHEMBL2599682 | 0.77 | SMN1; SMN2 (0.37) | PRKDCKDM4EALDH1A1GAA | |
| SCHEMBL13219242 | 0.76 | PDK2 (0.33) | — | |
| SCHEMBL13699530 | 0.74 | ALDH1A1 (0.36) | KDM4EALDH1A1GAA | |
| SCHEMBL13240239 | 0.73 | KIF11 (0.36) | PRKDCKDM4EALDH1A1GAA | |
| SCHEMBL13488507 | 0.73 | MAPT (0.35) | KDM4EALDH1A1GAA | |
| SCHEMBL3028310 | 0.72 | CNR1 (0.34) | KDM4EALDH1A1 | |
| SCHEMBL2599693 | 0.72 | SMN1; SMN2 (0.37) | KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703978-B2 | Photochromic dichroic naphtho-pyrans and optical articles containing them | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2014-04-22 | — | — | US | claimed |
| EP-2098520-B1 | Photochromic dichroic naphtho-pyrans and optical articles containing them | ESSILOR INT (FR) | 2013-07-03 | — | — | EP | claimed |
| US-20110122475-A1 | PHOTOCHROMIC DICHROIC NAPHTHO-PYRANS AND OPTICAL ARTICLES CONTAINING THEM | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2011-05-26 | — | — | US | claimed |
| EP-2098520-A1 | Photochromic dichroic naphtho-pyrans and optical articles containing them | Essilor International (Compagnie Générale D'Optique) (FR) | 2009-09-09 | — | — | EP | claimed |
| US-8703978-B2 | Photochromic dichroic naphtho-pyrans and optical articles containing them | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2014-04-22 | — | — | US | disclosed |
| EP-2098520-B1 | Photochromic dichroic naphtho-pyrans and optical articles containing them | ESSILOR INT (FR) | 2013-07-03 | — | — | EP | disclosed |
| EP-2098520-B1 | Photochromic dichroic naphtho-pyrans and optical articles containing them | ESSILOR INT (FR) | 2013-07-03 | — | — | EP | disclosed |
| US-20110122475-A1 | PHOTOCHROMIC DICHROIC NAPHTHO-PYRANS AND OPTICAL ARTICLES CONTAINING THEM | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2011-05-26 | — | — | US | disclosed |
| US-20110122475-A1 | PHOTOCHROMIC DICHROIC NAPHTHO-PYRANS AND OPTICAL ARTICLES CONTAINING THEM | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2011-05-26 | — | — | US | disclosed |
| US-20110122475-A1 | PHOTOCHROMIC DICHROIC NAPHTHO-PYRANS AND OPTICAL ARTICLES CONTAINING THEM | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2011-05-26 | — | — | US | disclosed |
| WO-2009109546-A1 | PHOTOCHROMIC DICHROIC NAPHTHO-PYRANS AND OPTICAL ARTICLES CONTAINING THEM | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2009-09-11 | — | — | WO | disclosed |
| EP-2098520-A1 | Photochromic dichroic naphtho-pyrans and optical articles containing them | Essilor International (Compagnie Générale D'Optique) (FR) | 2009-09-09 | — | — | EP | disclosed |
| EP-2098520-A1 | Photochromic dichroic naphtho-pyrans and optical articles containing them | Essilor International (Compagnie Générale D'Optique) (FR) | 2009-09-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110122475-A1 | PHOTOCHROMIC DICHROIC NAPHTHO-PYRANS AND OPTICAL ARTICLES CONTAINING THEM | NR2E3, NR2C2, NR5A2 | PRKDC 4610/4885KDM4E 3858/4885ALDH1A1 1244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.