SCHEMBL17913047

SCHEMBL17913047

COc1ccc(NS(=O)(=O)c2ccc(C(C)=NNc3ccc(Cl)cc3)cc2)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.70
PPIA P62937 1/20 0.62
EGFR P00533 1/20 0.55
FGFR1 P11362 1/20 0.55
KDR P35968 1/20 0.55
SMN1; SMN2 Q16637 2/20 0.54
HPGD P15428 1/20 0.54
HDAC3 O15379 2/20 0.54
HDAC4 P56524 2/20 0.54
HDAC1 Q13547 2/20 0.54
HDAC7 Q8WUI4 2/20 0.54
HDAC2 Q92769 2/20 0.54
HDAC10 Q969S8 2/20 0.54
HDAC11 Q96DB2 2/20 0.54
HDAC8 Q9BY41 2/20 0.54
HDAC6 Q9UBN7 2/20 0.54
HDAC9 Q9UKV0 2/20 0.54
HDAC5 Q9UQL6 2/20 0.54
GAA P10253 2/20 0.53
LMNA P02545 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17913046 1.00 ALDH1A1 (0.70) ALDH1A1PPIAEGFRFGFR1KDR
SCHEMBL17913043 0.94 ALDH1A1 (0.60) ALDH1A1PPIASMN1; SMN2HPGDHDAC3
SCHEMBL17913042 0.94 ALDH1A1 (0.60) ALDH1A1PPIASMN1; SMN2HPGDHDAC3
SCHEMBL17913083 0.89 PGR (0.61) ALDH1A1SMN1; SMN2HPGDHDAC3HDAC4
SCHEMBL17913052 0.89 PGR (0.61) ALDH1A1SMN1; SMN2HPGDHDAC3HDAC4
SCHEMBL17913101 0.88 GAA (0.56) ALDH1A1SMN1; SMN2HPGDHDAC3HDAC4
SCHEMBL17913049 0.88 GAA (0.56) ALDH1A1SMN1; SMN2HPGDHDAC3HDAC4
SCHEMBL17913056 0.87 LMNA (0.62) ALDH1A1SMN1; SMN2HDAC3HDAC4HDAC1
SCHEMBL17913090 0.86 ALDH1A1 (0.71) ALDH1A1SMN1; SMN2HPGDHDAC3HDAC4
SCHEMBL789993 0.83 PPIA (0.79) ALDH1A1PPIASMN1; SMN2GAALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016111658-A1 SYNTHESIS OF THIOSEMICARBAZONE DERIVATIVES COMPRISING SULPHONAMIDE GROUP WITH POTENTIAL ANTICONVULSANT ACTIVITY IYIDOGAN AYSEGUL (TR) 2016-07-14 WO claimed
WO-2016111658-A1 SYNTHESIS OF THIOSEMICARBAZONE DERIVATIVES COMPRISING SULPHONAMIDE GROUP WITH POTENTIAL ANTICONVULSANT ACTIVITY IYIDOGAN AYSEGUL (TR) 2016-07-14 WO disclosed