Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | CES1 | P23141 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17913065 | 0.88 | MAPT (0.63) | CA12CA9TDP1MEN1KMT2A | |
| SCHEMBL17913047 | 0.87 | ALDH1A1 (0.70) | LMNAMEN1KMT2ACES1MAPT | |
| SCHEMBL17913046 | 0.87 | ALDH1A1 (0.70) | LMNAMEN1KMT2ACES1MAPT | |
| SCHEMBL17913102 | 0.86 | CA12 (0.56) | LMNACA12CA9TDP1MEN1 | |
| SCHEMBL17913083 | 0.85 | PGR (0.61) | LMNACA12CA9TDP1MEN1 | |
| SCHEMBL17913052 | 0.85 | PGR (0.61) | LMNACA12CA9TDP1MEN1 | |
| SCHEMBL17913039 | 0.84 | MEN1 (0.56) | LMNACA12CA9TDP1MEN1 | |
| SCHEMBL23392561 | 0.84 | MEN1 (0.64) | LMNATDP1MEN1KMT2AMAPT | |
| SCHEMBL10403469 | 0.84 | MEN1 (0.64) | LMNATDP1MEN1KMT2AMAPT | |
| SCHEMBL17913042 | 0.80 | ALDH1A1 (0.60) | LMNATDP1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016111658-A1 | SYNTHESIS OF THIOSEMICARBAZONE DERIVATIVES COMPRISING SULPHONAMIDE GROUP WITH POTENTIAL ANTICONVULSANT ACTIVITY | IYIDOGAN AYSEGUL (TR) | 2016-07-14 | — | — | WO | disclosed |