Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 10/20 | 0.67 |
| ▸ | LMNA | P02545 | 6/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17913062 | 0.91 | TDP1 (0.69) | TDP1LMNAALOX12ALDH1A1HTT | |
| SCHEMBL17913048 | 0.89 | ALOX12 (0.67) | TDP1LMNAALOX12ALDH1A1HTT | |
| SCHEMBL17913041 | 0.85 | ALDH1A1 (0.57) | TDP1LMNAALOX12ALDH1A1MAPT | |
| SCHEMBL17913039 | 0.79 | MEN1 (0.56) | TDP1LMNAALOX12ALDH1A1MAPT | |
| SCHEMBL17913038 | 0.79 | FAAH (0.55) | TDP1LMNAALOX12ALDH1A1HTT | |
| SCHEMBL17913070 | 0.78 | PPIA (0.59) | TDP1LMNAALOX12ALDH1A1HTT | |
| SCHEMBL17913095 | 0.78 | ALDH1A1 (0.56) | TDP1LMNAALOX12ALDH1A1HTT | |
| SCHEMBL17913097 | 0.78 | PPIA (0.59) | TDP1LMNAALOX12ALDH1A1HTT | |
| SCHEMBL17913099 | 0.77 | CA12 (0.56) | ALDH1A1MEN1KMT2ACA12CA9 | |
| SCHEMBL17913096 | 0.76 | MAPT (0.51) | TDP1LMNAALOX12ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016111658-A1 | SYNTHESIS OF THIOSEMICARBAZONE DERIVATIVES COMPRISING SULPHONAMIDE GROUP WITH POTENTIAL ANTICONVULSANT ACTIVITY | IYIDOGAN AYSEGUL (TR) | 2016-07-14 | — | — | WO | claimed |