Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA8 | P11142 | 3/20 | 0.55 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HBB | P68871 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.52 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.51 |
| ▸ | GAPDH | P04406 | 2/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.51 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18464494 | 0.89 | ADK (0.51) | HSPA8HSPA5CDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL22315144 | 0.88 | ADORA3 (0.51) | HSPA8HSPA5CDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL15746955 | 0.87 | HSPA5 (0.45) | HSPA8HSPA5CDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL19007434 | 0.86 | HSPA5 (0.46) | HSPA8HSPA5CDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL23114970 | 0.85 | HSPA8 (0.40) | HSPA8HSPA5CDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL1740449 | 0.83 | HSPA5 (0.63) | HSPA8HSPA5CDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL17472296 | 0.83 | HSPA8 (0.45) | HSPA8HSPA5CDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL20419157 | 0.81 | HSPA5 (0.61) | HSPA8HSPA5CDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL6380760 | 0.81 | HSPA8 (0.61) | HSPA8HSPA5CDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL20419330 | 0.78 | HSPA8 (0.58) | HSPA8HSPA5CDK5CDK5R1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9782462-B2 | Modified polynucleotides for the production of proteins associated with human disease | MODERNATX, INC. (US) | 2017-10-10 | — | — | US | disclosed |
| US-20170028085-A1 | MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF NUCLEAR PROTEINS | MODERNATX INC (US) | 2017-02-02 | — | — | US | disclosed |
| US-20160199513-A1 | MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE | ARES CAPITAL CORPORATION, AS AGENT | 2016-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160199513-A1 | MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE | POLRMT, POLM, POLN | HSPA8 1177/4885HSPA5 847/4885CDK5 2861/4885 |
| US-20170028085-A1 | MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF NUCLEAR PROTEINS | POLN, POLRMT, MSH2 | HSPA8 1575/4885HSPA5 1404/4885CDK5 2296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.