Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYTH3 | O43739 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
| ▸ | EPN1 | Q9Y6I3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26820 | 0.83 | HPGD (0.54) | HPGDHCAR2DAOCYTH3BTK | |
| Hydrochloric Acid SCHEMBL27727584 | 0.81 | HPGD (0.52) | HPGDHCAR2DAOCYTH3BTK | |
| SCHEMBL42514 | 0.78 | HPGD (0.52) | HPGDMAPTLMNAKMT2AHCAR2 | |
| SCHEMBL5013388 | 0.78 | HPGD (0.52) | HPGDMAPTLMNAHCAR2DAO | |
| SCHEMBL14620257 | 0.74 | HPGD (0.49) | HPGDMAPTHCAR2DAODYRK1A | |
| SCHEMBL6305513 | 0.74 | HPGD (0.49) | HPGDLMNAMEN1KMT2AHCAR2 | |
| SCHEMBL18680106 | 0.74 | HPGD (0.49) | HPGDMAPTLMNAMEN1KMT2A | |
| SCHEMBL25449 | 0.74 | MAPK1 (0.57) | HPGDMAPTMEN1KMT2AHCAR2 | |
| SCHEMBL4755850 | 0.73 | MAPK1 (0.51) | HPGDMEN1KMT2AHCAR2DAO | |
| SCHEMBL9934565 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108644-B1 | N-(Methyl)-pyridin-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins | AC IMMUNE SA (CH) | 2016-07-20 | — | — | EP | disclosed |