Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19757971 | 0.89 | DPP7 (0.46) | DPP7SIGMAR1LMNAP2RX4KDM4E | |
| SCHEMBL20193875 | 0.83 | DPP7 (0.47) | DPP7SIGMAR1P2RX4KDM4EMEN1 | |
| SCHEMBL14902497 | 0.81 | LMNA (0.50) | DPP7SIGMAR1LMNAP2RX4KDM4E | |
| SCHEMBL20193888 | 0.80 | ALDH1A1 (0.47) | KDM4ENPC1OPRM1ALDH1A1 | |
| SCHEMBL14263122 | 0.80 | KCNH2 (0.56) | DPP7SIGMAR1LMNAP2RX4KDM4E | |
| SCHEMBL314627 | 0.78 | FAAH (0.62) | DPP7KDM4EMEN1KMT2A | |
| SCHEMBL14902453 | 0.77 | DPP7 (0.49) | DPP7SIGMAR1LMNAP2RX4KDM4E | |
| SCHEMBL4981955 | 0.76 | HSD11B1 (0.59) | DPP7P2RX4KDM4EOPRM1ALDH1A1 | |
| SCHEMBL25862937 | 0.72 | KDM4E (0.57) | SIGMAR1LMNAKDM4EHRH3ALDH1A1 | |
| SCHEMBL1912707 | 0.71 | OPRD1 (0.49) | KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016113168-A1 | 2-(PYRAZIN-2-YLCARBONYLAMINOMETHYL)BENZIMIDAZOLIUM COMPOUNDS AS EPITHELIAL SODIUM CHANNEL INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-07-21 | — | — | WO | disclosed |