Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MLYCD | O95822 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19698275 | 0.93 | SMN1; SMN2 (0.40) | SIGMAR1ALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL17944164 | 0.93 | HDAC3 (0.37) | SIGMAR1ALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL19698272 | 0.91 | HDAC3 (0.39) | SIGMAR1ALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL19698269 | 0.91 | SMN1; SMN2 (0.44) | SIGMAR1ALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL19698292 | 0.90 | SMN1; SMN2 (0.46) | SIGMAR1ALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL19698267 | 0.90 | SMN1; SMN2 (0.46) | SIGMAR1ALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL19698419 | 0.90 | SMN1; SMN2 (0.35) | SIGMAR1ALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL16938158 | 0.88 | SMN1; SMN2 (0.37) | ALDH1A1HPGDHTTSMN1; SMN2HDAC3 | |
| SCHEMBL19703747 | 0.88 | SMN1; SMN2 (0.45) | SIGMAR1ALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL10017830 | 0.88 | KMT2A (0.36) | ALDH1A1HPGDHTTSMN1; SMN2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3250232-B1 | BRANCHED AND LINEAR CHIMERIC COMPOUNDS, POLYNUCLEOTIDES, USES AND METHODS FOR PREPARATION THEREOF | DYNAVAX TECH CORP (US) | 2020-04-29 | — | — | EP | disclosed |
| US-10548975-B2 | Branched chimeric compounds, and methods of use thereof | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2020-02-04 | — | — | US | disclosed |
| US-20190240323-A1 | BRANCHED CHIMERIC COMPOUNDS, AND METHODS OF USE THEREOF | DYNAVAX TECHNOLOGIES CORPORATION | 2019-08-08 | — | — | US | disclosed |
| US-10350290-B2 | Linear chimeric compounds and methods of use thereof | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2019-07-16 | — | — | US | disclosed |
| US-9950064-B2 | Branched and linear chimeric compounds, polynucleotides, uses and methods for preparation thereof | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2018-04-24 | — | — | US | disclosed |
| US-9950064-B2 | Branched and linear chimeric compounds, polynucleotides, uses and methods for preparation thereof | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2018-04-24 | — | — | US | disclosed |
| US-9938323-B2 | Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase | NOVARTIS AG (CH) | 2018-04-10 | — | — | US | disclosed |
| US-9938323-B2 | Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase | NOVARTIS AG (CH) | 2018-04-10 | — | — | US | disclosed |
| US-20170355731-A1 | AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE | NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC., DBA GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION | 2017-12-14 | — | — | US | disclosed |
| US-20170355731-A1 | AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE | NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC., DBA GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION | 2017-12-14 | — | — | US | disclosed |
| US-20160213774-A1 | BRANCHED AND LINEAR CHIMERIC COMPOUNDS, POLYNUCLEOTIDES, USES AND METHODS FOR PREPARATION THEREOF | DYNAVAX TECHNOLOGIES CORPORATION | 2016-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160213774-A1 | BRANCHED AND LINEAR CHIMERIC COMPOUNDS, POLYNUCLEOTIDES, USES AND METHODS FOR PREPARATION THEREOF | PAICS, PBK, PHAX | SIGMAR1 3011/4885ALDH1A1 4448/4885HPGD 4362/4885 |
| US-10350290-B2 | Linear chimeric compounds and methods of use thereof | PAICS, HAVCR2, DCLRE1B | SIGMAR1 2306/4885ALDH1A1 4311/4885HPGD 4469/4885 |
| US-20170355731-A1 | AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE | RNGTT, RNASE1, RNMT | SIGMAR1 2243/4885ALDH1A1 3212/4885HPGD 3861/4885 |
| US-20190240323-A1 | BRANCHED CHIMERIC COMPOUNDS, AND METHODS OF USE THEREOF | PAICS, PBK, HAVCR2 | SIGMAR1 2577/4885ALDH1A1 3972/4885HPGD 4360/4885 |
| US-10548975-B2 | Branched chimeric compounds, and methods of use thereof | PAICS, PBK, HAVCR2 | SIGMAR1 2577/4885ALDH1A1 3972/4885HPGD 4360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.