Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.69 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.69 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.61 |
| ▸ | HTR1A | P08908 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.61 |
| ▸ | MPO | P05164 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | NQO2 | P16083 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14961000 | 0.93 | MTNR1A (0.66) | MTNR1AMTNR1BHTR1AKDM4EMEN1 | |
| SCHEMBL17949517 | 0.92 | MTNR1A (0.65) | MTNR1AMTNR1BHTR1AKDM4EMEN1 | |
| SCHEMBL5616635 | 0.89 | MTNR1A (0.85) | MTNR1AMTNR1BHTR1AKDM4EMEN1 | |
| SCHEMBL8569058 | 0.88 | MTNR1A (0.79) | MTNR1AMTNR1BHTR1AKDM4EMEN1 | |
| SCHEMBL4686540 | 0.88 | MTNR1A (0.62) | MTNR1AMTNR1BTRPV1HTR1AKDM4E | |
| SCHEMBL14907346 | 0.87 | MTNR1A (0.67) | MTNR1AMTNR1BTRPV1HTR1AKDM4E | |
| SCHEMBL7731853 | 0.87 | TRPM8 (0.77) | MTNR1AMTNR1BKDM4ETRPM8HTR1D | |
| SCHEMBL14907361 | 0.86 | MTNR1A (0.75) | MTNR1AMTNR1BTRPV1HTR1AKDM4E | |
| SCHEMBL8206907 | 0.85 | TRPM8 (0.73) | MTNR1AMTNR1BTRPM8HTR1D | |
| SCHEMBL8712198 | 0.84 | MPO (0.65) | MTNR1AMTNR1BTRPV1HTR1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160214934-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2016-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160214934-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2, BCL2L1 | MTNR1A 748/4885MTNR1B 1115/4885TRPV1 4136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.