Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PTGIR | P43119 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25541644 | 0.82 | POLB (0.58) | HRH3SPHK1LTA4HACHEMEN1 | |
| SCHEMBL13293708 | 0.80 | HRH3 (0.64) | HRH3MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL8099793 | 0.78 | ALDH1A1 (0.59) | HRH3LTA4HACHEMEN1KMT2A | |
| SCHEMBL3614984 | 0.78 | ALDH1A1 (0.59) | HRH3LTA4HACHEMEN1KMT2A | |
| SCHEMBL1021686 | 0.76 | ALDH1A1 (0.60) | HRH3LTA4HACHEMEN1KMT2A | |
| SCHEMBL3181878 | 0.76 | ALDH1A1 (0.63) | HRH3SPHK1LTA4HACHEMEN1 | |
| SCHEMBL17967832 | 0.75 | KDM4E (0.58) | HRH3MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL8804601 | 0.75 | ALDH1A1 (0.67) | HRH3SPHK1LTA4HACHEMEN1 | |
| SCHEMBL15033034 | 0.75 | ACHE (0.55) | HRH3LTA4HACHESIGMAR1 | |
| SCHEMBL8108384 | 0.75 | BCHE (0.55) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016124553-A1 | 2-PHENYL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY | KANCERA AB (SE) | 2016-08-11 | — | — | WO | disclosed |