Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.64 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PTGIR | P43119 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NCF1 | P14598 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.50 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13293323 | 0.81 | HRH3 (0.69) | HRH3HRH4ALDH1A1KDM4EMEN1 | |
| SCHEMBL4277270 | 0.80 | HRH3 (1.00) | HRH3HRH4ALDH1A1KDM4EMEN1 | |
| SCHEMBL17967907 | 0.80 | HRH3 (0.46) | HRH3ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL155167 | 0.79 | HRH3 (0.78) | HRH3HRH4ALDH1A1KDM4EMEN1 | |
| SCHEMBL14418007 | 0.79 | CHRNB2 (0.62) | ALDH1A1KDM4EGFER | |
| Hydrochloric Acid SCHEMBL7468055 | 0.78 | HRH3 (0.95) | HRH3HRH4ALDH1A1KDM4EMEN1 | |
| SCHEMBL11201497 | 0.78 | HRH3 (0.94) | HRH3HRH4ALDH1A1KDM4ECYP2D6 | |
| SCHEMBL24047167 | 0.77 | HRH3 (0.62) | HRH3HRH4ALDH1A1KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL7406183 | 0.77 | HRH3 (0.75) | HRH3HRH4ALDH1A1KDM4EMEN1 | |
| SCHEMBL4750722 | 0.77 | ADRA1D (0.56) | KMT2APOLBMBTD1L3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010065782-A1 | METHOD FOR TREATING PULMONARY DISEASES USING RHO KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. (US) | 2010-06-10 | — | — | WO | disclosed |
| WO-2009158587-A1 | METHOD FOR TREATING PULMONARY DISEASES USING RHO KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. (US) | 2009-12-30 | — | — | WO | disclosed |