Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | UBE2N | P61088 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10945 | 0.90 | HTT (0.55) | HTTSMN1; SMN2RXFP1ADORA2BALDH1A1 | |
| SCHEMBL130916 | 0.77 | ADORA2A (0.48) | SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL1944405 | 0.71 | ADORA2B (1.00) | HTTSMN1; SMN2RXFP1ADORA2BALDH1A1 | |
| SCHEMBL20561098 | 0.70 | LMNA (0.80) | HTTSMN1; SMN2RXFP1ADORA2BALDH1A1 | |
| SCHEMBL20561815 | 0.68 | ADORA2B (0.71) | HTTSMN1; SMN2RXFP1ADORA2BALDH1A1 | |
| SCHEMBL11438 | 0.68 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1TSHRLMNAMAPK1 | |
| SCHEMBL20561812 | 0.68 | SMN1; SMN2 (0.72) | HTTSMN1; SMN2RXFP1ADORA2BALDH1A1 | |
| SCHEMBL4539991 | 0.68 | ADORA2B (0.53) | HTTSMN1; SMN2RXFP1ADORA2BALDH1A1 | |
| SCHEMBL10649591 | 0.68 | HTT (0.67) | HTTSMN1; SMN2RXFP1ADORA2BALDH1A1 | |
| SCHEMBL29651707 | 0.67 | CYP11B1 (0.44) | HTTSMN1; SMN2ALDH1A1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3050876-A2 | KINASE MODULATORS | Rhizen Pharmaceuticals S.A. (CH) | 2016-08-03 | — | — | EP | disclosed |