Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16578561 | 0.91 | ALDH1A1 (0.49) | SIGMAR1MTNR1AMTNR1BHRH3DAO | |
| SCHEMBL17970934 | 0.86 | GSK3A (0.44) | SIGMAR1DAOL3MBTL1ALDH1A1GAA | |
| SCHEMBL17970920 | 0.83 | ADORA2A (0.44) | DAOALDH1A1POLBALOX15 | |
| SCHEMBL17970910 | 0.83 | SMN1; SMN2 (0.47) | ALDH1A1GAAPOLB | |
| SCHEMBL17970902 | 0.81 | HTT (0.43) | SIGMAR1DAOL3MBTL1POLB | |
| SCHEMBL20751234 | 0.78 | ALDH1A1 (0.47) | SIGMAR1HRH3DAOHDAC3HDAC4 | |
| SCHEMBL17970921 | 0.77 | MTNR1A (0.43) | SIGMAR1MTNR1AMTNR1BHRH3DAO | |
| SCHEMBL17970923 | 0.76 | L3MBTL1 (0.53) | L3MBTL1ALDH1A1PKMALOX15 | |
| SCHEMBL16578654 | 0.74 | HSP90AA1 (0.47) | ALDH1A1GAA | |
| SCHEMBL17970907 | 0.73 | PARP1 (0.42) | HDAC1HDAC7L3MBTL1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160221963-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | Janssen Pharmaceuticals, Inc. | 2016-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160221963-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | PDXK, PNPO, PLPBP | SIGMAR1 3789/4885MTNR1A 994/4885MTNR1B 666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.