Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 3/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1792649 | 0.85 | CHRNA7 (0.39) | CHRNA7CYP2D6CYP1A2 | |
| SCHEMBL1797114 | 0.83 | KCNH2 (0.44) | CHRNB2CHRNA7CHRNA4KCNH2 | |
| SCHEMBL1792193 | 0.81 | CHRNB2 (0.39) | CHRNB2CHRNA7CHRNA4KCNH2 | |
| SCHEMBL1802902 | 0.79 | CHRNB2 (0.51) | CHRNB2CHRNA7CHRNA4CYP2D6HRH4 | |
| SCHEMBL6332378 | 0.78 | ALDH1A1 (0.41) | CHRNB2CHRNA7CHRNA4CYP2D6CYP1A2 | |
| SCHEMBL1791683 | 0.75 | GHSR (0.42) | CHRNA7KCNH2CYP2D6CYP1A2GHSR | |
| SCHEMBL925343 | 0.73 | CHRNB2 (0.67) | CHRNB2CHRNA7CHRNA4KCNH2HRH4 | |
| SCHEMBL928324 | 0.72 | USP30 (0.36) | CHRNA7CYP2D6CYP1A2 | |
| SCHEMBL6324089 | 0.72 | CHRNA7 (0.40) | CHRNA7KCNH2CYP2D6CYP1A2 | |
| SCHEMBL1795196 | 0.70 | CHRNB2 (0.35) | CHRNB2CHRNA7CHRNA4CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2316836-A1 | Substituted diazabicycloalkane derivatives as ligands at alpha 7 nicotinic acetylcholine receptors | Abbott Laboratories (US) | 2011-05-04 | — | — | EP | disclosed |