Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17381367 | 0.91 | CYP2C19 (0.49) | CYP2C19ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL10307777 | 0.90 | CYP2C19 (0.52) | CYP2C19ALDH1A1EPHX1HPGDSMN1; SMN2 | |
| SCHEMBL22299026 | 0.90 | CYP2C19 (0.48) | CYP2C19ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL13333202 | 0.90 | CYP2C19 (0.50) | CYP2C19ALDH1A1EPHX1HPGDSMN1; SMN2 | |
| SCHEMBL16282701 | 0.81 | ALDH1A1 (0.49) | CYP2C19ALDH1A1SMN1; SMN2LMNAMAPT | |
| Cpi 613 SCHEMBL13333201 | 0.81 | CYP2C19 (0.59) | CYP2C19ALDH1A1HPGDSMN1; SMN2LMNA | |
| Cpi 613 SCHEMBL1062218 | 0.81 | CYP2C19 (0.59) | CYP2C19ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL22299081 | 0.80 | CYP2C19 (0.58) | CYP2C19ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL17381514 | 0.80 | CYP2C19 (0.58) | CYP2C19ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL13333203 | 0.78 | CYP2C19 (0.46) | CYP2C19ALDH1A1HPGDSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180104341-A1 | PHARMACEUTICAL FORMULATIONS CONTAINING LIPOIC ACID DERIVATIVES | RAFAEL PHARMACEUTICALS, INC. | 2018-04-19 | — | — | US | disclosed |
| US-9872845-B2 | Methods of treating myeloma and lymphoma using compositions containing an ion pair of a lipoic acid derivative | RAFAEL PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |
| US-9839691-B2 | Methods of treating pancreatic and ovarian cancers using compositions containing an ion pair of a lipoic acid derivative | RAFAEL PHARMACEUTICALS, INC. (US) | 2017-12-12 | — | — | US | disclosed |
| US-20170056355-A1 | PHARMACEUTICAL FORMULATIONS CONTAINING LIPOIC ACID DERIVATIVES | CORNERSTONE PHARMACEUTICALS, INC. | 2017-03-02 | — | — | US | disclosed |
| US-20160220678-A1 | PHARMACEUTICAL FORMULATIONS CONTAINING LIPOIC ACID DERIVATIVES | RAFAEL PHARMACEUTICALS, INC. | 2016-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180104341-A1 | PHARMACEUTICAL FORMULATIONS CONTAINING LIPOIC ACID DERIVATIVES | SLC25A1, SLC25A21, SLC25A11 | CYP2C19 500/4885ALDH1A1 783/4885EPHX1 3631/4885 |
| US-20160220678-A1 | PHARMACEUTICAL FORMULATIONS CONTAINING LIPOIC ACID DERIVATIVES | SLC25A1, SLC25A21, SLC25A11 | CYP2C19 500/4885ALDH1A1 783/4885EPHX1 3631/4885 |
| US-20170056355-A1 | PHARMACEUTICAL FORMULATIONS CONTAINING LIPOIC ACID DERIVATIVES | LIPA, LIPC, TTPA | CYP2C19 295/4885ALDH1A1 808/4885EPHX1 3489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.