Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL935744 | 0.84 | MLYCD (0.41) | CA2CAMK2AALDH1A1MLYCDESR1 | |
| SCHEMBL3282238 | 0.84 | CA2 (0.41) | CA2CAMK2AALDH1A1MLYCDESR1 | |
| SCHEMBL547256 | 0.83 | ALDH1A1 (0.52) | ALDH1A1 | |
| SCHEMBL3656192 | 0.82 | ALDH1A1 (0.51) | CA2CAMK2AALDH1A1PDK1CA12 | |
| SCHEMBL6470863 | 0.81 | ESR1 (0.41) | ALDH1A1MLYCDLTB4R2ESR1ESR2 | |
| SCHEMBL6370928 | 0.81 | LMNA (0.41) | CA2CAMK2AALDH1A1MLYCDCA12 | |
| SCHEMBL3661402 | 0.80 | ALDH1A1 (0.60) | ALDH1A1PDK1LTB4R2ESR1ESR2 | |
| SCHEMBL10773101 | 0.80 | CA12 (0.40) | CA2MLYCDCA12CA1CA7 | |
| SCHEMBL5702149 | 0.79 | ALDH1A1 (0.53) | ALDH1A1LTB4R2ESR1ESR2 | |
| SCHEMBL11297196 | 0.78 | CA2 (0.46) | CA2CAMK2AALDH1A1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1908850-B1 | Target for therapy of cognitive impairment | UNIV JOHNS HOPKINS (US) | 2012-01-04 | — | — | EP | disclosed |
| US-20080177061-A1 | cephalosporins and derivatives that beneficially modulate expression of genes associated with promoting or preserving cognitive function during aging | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2008-07-24 | — | — | US | disclosed |
| EP-1908850-A1 | Target for therapy of cognitive impairment | The Johns Hopkins University (US) | 2008-04-09 | — | — | EP | disclosed |
| EP-1897959-A1 | Target for therapy of cognitive impairment | The Johns Hopkins University (US) | 2008-03-12 | — | — | EP | disclosed |
| EP-1567674-A4 | TARGET FOR THERAPY OF COGNITIVE IMPAIRMENT | UNIV JOHNS HOPKINS (US) | 2007-09-26 | — | — | EP | disclosed |
| EP-1567674-A2 | TARGET FOR THERAPY OF COGNITIVE IMPAIRMENT | The Johns Hopkins University (US) | 2005-08-31 | — | — | EP | disclosed |
| US-20040191803-A1 | Target for therapy of cognitive impairment | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2004-09-30 | — | — | US | disclosed |
| WO-2004048551-A2 | TARGET FOR THERAPY OF COGNITIVE IMPAIRMENT | THE JOHNS HOPKINS UNIVERSITY (US) | 2004-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080177061-A1 | cephalosporins and derivatives that beneficially modulate expression of genes associated with promoting or preserving cognitive function during aging | PSEN2, ANKRD52, PSEN1 | CA2 4560/4885CAMK2A 189/4885ALDH1A1 3768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.