Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methapyrilene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.52 |
| ▸ | DRD1 | P21728 | 2/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methapyrilene SCHEMBL4902232 | 0.81 | CYP2D6 (0.80) | CYP2D6CHRM2ADRA2AADRA2BDRD1 | |
| Methapyrilene SCHEMBL19209 | 0.72 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2AADRA2BDRD1 | |
| Methapyrilene SCHEMBL498484 | 0.71 | KDM4E (1.00) | CYP2D6CHRM2ADRA2AADRA2BDRD1 | |
| Methapyrilene SCHEMBL745149 | 0.71 | CYP2D6 (0.97) | CYP2D6CHRM2ADRA2AADRA2BDRD1 | |
| Methapyrilene SCHEMBL1074644 | 0.70 | CYP2D6 (0.95) | CYP2D6CHRM2ADRA2AADRA2BDRD1 | |
| Methapyrilene SCHEMBL7121305 | 0.67 | CYP2D6 (0.86) | CYP2D6CHRM2ADRA2AADRA2BDRD1 | |
| Methapyrilene SCHEMBL28140755 | 0.67 | CYP2D6 (0.86) | CYP2D6CHRM2ADRA2AADRA2BDRD1 | |
| Metaproterenol SCHEMBL8330430 | 0.66 | BLM (0.88) | CYP2D6SLC6A2HTR2ASLC6A4SLC6A3 | |
| Metaproterenol SCHEMBL9614523 | 0.66 | MEN1 (1.00) | CYP2D6SLC6A2HTR2ASLC6A4SLC6A3 | |
| Metaproterenol SCHEMBL41816 | 0.66 | MEN1 (1.00) | CYP2D6SLC6A2HTR2ASLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10149822-B2 | Compositions and methods for combination ingredient delivery | THE FIX, LLC (US) | 2018-12-11 | — | — | US | disclosed |
| US-20170020811-A1 | COMPOSITIONS AND METHODS FOR COMBINATION INGREDIENT DELIVERY | JOHNSON & WALES UNIVERSITY | 2017-01-26 | — | — | US | disclosed |
| US-9498435-B2 | Compositions and methods for combination ingredient delivery | THE FIX, LLC (US) | 2016-11-22 | — | — | US | disclosed |
| US-20160256383-A1 | COMPOSITIONS AND METHODS FOR COMBINATION INGREDIENT DELIVERY | JOHNSON & WALES UNIVERSITY | 2016-09-08 | — | — | US | disclosed |
| WO-2016130830-A1 | COMPOSITIONS AND METHODS FOR COMBINATION INGREDIENT DELIVERY | THE FIX, LLC (US) | 2016-08-18 | — | — | WO | disclosed |