Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 8/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.45 |
| ▸ | USP2 | O75604 | 6/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2941350 | 0.83 | CYP2D6 (0.50) | CYP2D6CYP2C9TSHRCYP1A2CYP2C19 | |
| SCHEMBL1799979 | 0.81 | CYP3A4 (0.40) | CYP2D6CYP2C9TSHRCYP2C19ALDH1A1 | |
| SCHEMBL1800729 | 0.80 | CYP2D6 (0.50) | CYP2D6CYP2C9TSHRCYP1A2CYP2C19 | |
| SCHEMBL1799769 | 0.79 | CYP3A4 (0.36) | CYP2C9CYP2C19ALDH1A1CYP3A4USP2 | |
| SCHEMBL1800528 | 0.78 | ADAMTS5 (0.34) | — | |
| SCHEMBL1803452 | 0.78 | NPC1 (0.52) | CYP2D6CYP2C9TSHRCYP1A2CYP2C19 | |
| SCHEMBL1801620 | 0.78 | CHRM2 (0.39) | CYP2C9ALDH1A1CHRM2SMN1; SMN2 | |
| SCHEMBL1800968 | 0.77 | CYP3A4 (0.41) | CYP2D6CYP2C9TSHRCYP2C19ALDH1A1 | |
| SCHEMBL1800768 | 0.75 | KMT2A (0.43) | CYP2D6CYP2C9TSHRCYP2C19HIF1A | |
| SCHEMBL4006906 | 0.75 | CYP2D6 (0.53) | CYP2D6CYP2C9TSHRCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951815-B2 | Substituted 1,4,8-triazaspiro [4,5]decan-2-one compounds | GRUENENTHAL GMBH (DE) | 2011-05-31 | — | — | US | claimed |
| US-20070015784-A1 | Subsitituted 1,4,8- triazaspiro [4,5]decan-2-one compounds | GRUENENTHAL GMBH (DE) | 2007-01-18 | — | — | US | claimed |
| US-7951815-B2 | Substituted 1,4,8-triazaspiro [4,5]decan-2-one compounds | GRUENENTHAL GMBH (DE) | 2011-05-31 | — | — | US | disclosed |
| US-20070015784-A1 | Subsitituted 1,4,8- triazaspiro [4,5]decan-2-one compounds | GRUENENTHAL GMBH (DE) | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015784-A1 | Subsitituted 1,4,8- triazaspiro [4,5]decan-2-one compounds | SI, SSTR4, SLC10A2 | CYP2D6 731/4885CYP2C9 429/4885TSHR 1666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.