Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 5/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | USP19 | O94966 | 3/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 5/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.30 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.30 |
| ▸ | EP300 | Q09472 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1799979 | 0.85 | CYP3A4 (0.40) | MME | |
| SCHEMBL1799769 | 0.83 | CYP3A4 (0.36) | USP19MMECCR5 | |
| SCHEMBL1797694 | 0.82 | CCR5 (0.33) | ADAMTS5ADAM17MMP2CCR5 | |
| SCHEMBL1798461 | 0.78 | CYP2D6 (0.48) | — | |
| SCHEMBL1800700 | 0.73 | CYP3A4 (0.37) | — | |
| SCHEMBL1800968 | 0.73 | CYP3A4 (0.41) | — | |
| SCHEMBL4285003 | 0.72 | MMP2 (0.33) | ADAMTS5ADAM17MMP2USP19 | |
| SCHEMBL1803789 | 0.72 | CHRM2 (0.45) | — | |
| SCHEMBL1798796 | 0.70 | KMT2A (0.37) | USP19 | |
| SCHEMBL1801126 | 0.69 | CCR5 (0.37) | ADAMTS5ADAM17MMP2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070015784-A1 | Subsitituted 1,4,8- triazaspiro [4,5]decan-2-one compounds | GRUENENTHAL GMBH (DE) | 2007-01-18 | — | — | US | claimed |
| US-7951815-B2 | Substituted 1,4,8-triazaspiro [4,5]decan-2-one compounds | GRUENENTHAL GMBH (DE) | 2011-05-31 | — | — | US | disclosed |
| US-20070015784-A1 | Subsitituted 1,4,8- triazaspiro [4,5]decan-2-one compounds | GRUENENTHAL GMBH (DE) | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015784-A1 | Subsitituted 1,4,8- triazaspiro [4,5]decan-2-one compounds | SI, SSTR4, SLC10A2 | ADAMTS5 251/4885ADAM17 2712/4885MMP2 1705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.