Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM4B | O94953 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16293825 | 0.80 | CHRM2 (0.39) | CHRM2MAOAKDM4AKDM4BKDM5C | |
| SCHEMBL16006933 | 0.75 | CXCR4 (0.37) | CHRM2MAOAKDM4AKDM4BKDM5C | |
| SCHEMBL16291866 | 0.70 | KDM5B (0.44) | KDM4AKDM4BKDM5CKDM5BALDH1A1 | |
| SCHEMBL18860206 | 0.64 | CHRM2 (0.42) | CHRM2SCN8AKDM4AKDM4BKDM5C | |
| SCHEMBL16006934 | 0.64 | KDM5B (0.49) | KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL653443 | 0.64 | MEN1 (0.56) | CHRM2MAOASIGMAR1MEN1KMT2A | |
| SCHEMBL16006938 | 0.64 | SIGMAR1 (0.54) | KDM5BSIRT2SIGMAR1MEN1ALDH1A1 | |
| SCHEMBL17984960 | 0.63 | CHRM2 (0.56) | CHRM2SCN8AMAOASIRT2ALDH1A1 | |
| SCHEMBL16293030 | 0.63 | TMEM97 (0.56) | KDM5BSIRT2SIGMAR1MEN1ALDH1A1 | |
| SCHEMBL12845427 | 0.63 | CTSB (0.36) | SIRT2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160237037-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. | 2016-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160237037-A1 | INHIBITORS OF HISTONE DEMETHYLASES | KDM1B, KDM1A, KDM3A | CHRM2 3004/4885SCN8A 3771/4885MAOA 1678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.