SCHEMBL1798922

SCHEMBL1798922

Cc1ccc([Si](C)(Cl)Cl)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 6/20 0.47
TDP1 Q9NUW8 1/20 0.47
ALDH1A1 P00352 3/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36
TSHR P16473 3/20 0.33
LMNA P02545 3/20 0.33
HPGD P15428 2/20 0.33
NOTUM Q6P988 1/20 0.33
ALOX12 P18054 1/20 0.33
NPC1 O15118 1/20 0.33
POLB P06746 1/20 0.33
NFKB1 P19838 1/20 0.33
RAB9A P51151 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HTR3E A5X5Y0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL703791 0.87 ALDH1A1 (0.36) ALDH1A1HPGD
SCHEMBL5034146 0.82 ACHE (0.47) ACHETDP1ALDH1A1CA1CA2
SCHEMBL80628 0.82 ACHE (0.47) ACHETDP1ALDH1A1CA1CA2
SCHEMBL301896 0.79 ACHE (0.50) ACHETDP1ALDH1A1CA1CA2
SCHEMBL1538600 0.79 ACHE (0.50) ACHETDP1ALDH1A1CA1CA2
SCHEMBL297883 0.79 ACHE (0.50) ACHETDP1ALDH1A1CA1CA2
SCHEMBL6477550 0.77 LMNA (0.47) TDP1ALDH1A1TSHRLMNANOTUM
SCHEMBL10317545 0.76 ACHE (0.40) ACHETDP1ALDH1A1CA1CA2
SCHEMBL987122 0.75 ACHE (0.53) ACHETDP1ALDH1A1CA1CA2
SCHEMBL1054613 0.75 ACHE (0.53) ACHETDP1ALDH1A1CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 214 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7524992-B2 Carbon-carbon bond creation method comprising the coupling of a transferable group and an acceptor group RHODIA CHIMIE (FR) 2009-04-28 US claimed
EP-1546250-B1 ORGANOSILICON COMPOUNDS AND BLENDS FOR TREATING SILICA DOW CORNING (US) 2007-12-19 EP claimed
JP-2007504118-A 2007-03-01 JP claimed
US-20070010683-A1 Carbon-carbon bond creation method comprising the coupling of a transferable group and an acceptor group RHODIA-CHIMIE (FR) 2007-01-11 US claimed
CN-1863751-A Method for producing a carbon-carbon bond by coupling a transferable group and an acceptor group RHONE POULENC CHIMIE (FR) 2006-11-15 CN claimed
EP-1658249-A2 CARBON-CARBON BOND CREATION METHOD COMPRISING THE COUPLING OF A TRANSFERABLE GROUP AND AN ACCEPTOR GROUP Rhodia Chimie (FR) 2006-05-24 EP claimed
EP-1546250-A2 ORGANOSILICON COMPOUNDS AND BLENDS FOR TREATING SILICA Dow Corning Corporation (US) 2005-06-29 EP claimed
WO-2005023735-A2 CARBON-CARBON BOND CREATION METHOD COMPRISING THE COUPLING OF A TRANSFERABLE GROUP AND AN ACCEPTOR GROUP RHODIA CHIMIE (FR) 2005-03-17 WO claimed
WO-2004024812-A2 ORGANOSILICON COMPOUNDS AND BLENDS FOR TREATING SILICA DOW CORNING CORPORATION (US) 2004-03-25 WO claimed
US-6706398-B1 FORMING HIGHER HYDROPHOBICITY FILLERS; SURFACE TREATMENT WITH COMBINATION OF MONOMERIC DICHLOROSILANES AND TRIALKOXYSILANES DOW CORNING CORPORATION 2004-03-16 US claimed
US-6046293-A Solid-liquid phase interfacial polymerization UNIVERSITY OF SOUTH AUSTRALIA (AU) 2000-04-04 US claimed
EP-0799851-A2 Preparation of polyorganosilloxanes by interfacial polymerization DOW CORNING CORPORATION (US) 1997-10-08 EP claimed
US-5629401-A Preparation of polyorganosiloxanes by interfacial polymerization DOW CORNING CORPORATION (US) 1997-05-13 US claimed
US-4997899-A Organosilicon or germanium polymers NIPPON TELEGRAPH AND TELEPHONE CORPORATION (JP) 1991-03-05 US claimed
US-4839451-A Processes for the preparation of polysilylenes XEROX CORPORATION (US) 1989-06-13 US claimed
US-4659852-A STARTING MATERIAL FOR SILICONE RESINS SHIN-ETSU CHEMICAL CO., LTD. (JP) 1987-04-21 US claimed
EP-3782599-B1 DENTAL POLYMERIZABLE COMPOSITION BASED ON CONDENSED SILANES VOCO GMBH (DE) 2025-09-17 EP disclosed
US-12109812-B2 Ink jet printing method and ink jet printing apparatus SEIKO EPSON CORPORATION (JP) 2024-10-08 US disclosed
US-4659852-A STARTING MATERIAL FOR SILICONE RESINS SHIN-ETSU CHEMICAL CO., LTD. (JP) 1987-04-21 US disclosed
US-3987061-A METAL COMPLEXING AGENTS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070010683-A1 Carbon-carbon bond creation method comprising the coupling of a transferable group and an acceptor group C9, NUDC, PIK3C2A ACHE 3499/4885TDP1 4760/4885ALDH1A1 2959/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.