SCHEMBL80628

SCHEMBL80628

Cc1ccc([Si](C)(C)Cl)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 6/20 0.47
TDP1 Q9NUW8 2/20 0.47
ALDH1A1 P00352 3/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36
POLB P06746 2/20 0.36
RAB9A P51151 2/20 0.36
KDM4E B2RXH2 2/20 0.36
MAPT P10636 1/20 0.36
RECQL P46063 1/20 0.36
MDM2 Q00987 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
TSHR P16473 3/20 0.33
LMNA P02545 3/20 0.33
NOTUM Q6P988 1/20 0.33
ALOX12 P18054 1/20 0.33
NPC1 O15118 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL705667 0.87 ALDH1A1 (0.36) ALDH1A1HPGD
SCHEMBL5034146 0.82 ACHE (0.47) ACHETDP1ALDH1A1CA1CA2
SCHEMBL1798922 0.82 ACHE (0.47) ACHETDP1ALDH1A1CA1CA2
SCHEMBL801429 0.79
SCHEMBL10318540 0.79 NR1H2 (0.41)
SCHEMBL297883 0.79 ACHE (0.50) ACHETDP1ALDH1A1CA1CA2
SCHEMBL301896 0.79 ACHE (0.50) ACHETDP1ALDH1A1CA1CA2
SCHEMBL30965311 0.79 ESR1 (0.44) HPGD
SCHEMBL1538600 0.79 ACHE (0.50) ACHETDP1ALDH1A1CA1CA2
SCHEMBL7913246 0.77 LMNA (0.47) ALDH1A1RAB9AKDM4ETSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 237 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103570874-A Method for terminating copolymerization between conjugated diene and vinyl aromatic hydrocarbon CHINA PETROLEUM & CHEMICAL 2014-02-12 CN claimed
CN-103570851-A Method for terminating conjugated diene homopolymerization CHINA PETROLEUM & CHEMICAL 2014-02-12 CN claimed
US-20250171469-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2025-05-29 US disclosed
US-12109812-B2 Ink jet printing method and ink jet printing apparatus SEIKO EPSON CORPORATION (JP) 2024-10-08 US disclosed
EP-3743464-B1 ORGANIC-INORGANIC AEROGEL COMPOSITES, METHODS AND USES THEREOF BRONX CREATIVE&DESIGN CENTRE PTE LTD (SG) 2024-03-06 EP disclosed
US-20230312616-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2023-10-05 US disclosed
US-20230312616-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2023-10-05 US disclosed
US-20230312616-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2023-10-05 US disclosed
US-20230250250-A1 Organic-inorganic Aerogel Composites, Methods and Uses Thereof BRONX CREATIVE & DESIGN CENTRE PTE LTD (SG) 2023-08-10 US disclosed
CN-114055975-B Ink jet recording method and ink jet recording apparatus 精工爱普生株式会社 2023-05-12 CN disclosed
US-20220355262-A1 SYSTEM AND METHOD FOR MANUFACTURING WATER-BASED HYDROPHOBIC AEROGELS AND AEROGEL COMPOSITES KROSSLINKER PTE LTD (SG) 2022-11-10 US disclosed
WO-2000040593-A2 TARGET MOLECULE ATTACHMENT TO SURFACES SURMODICS, INC. (US) 2000-07-13 WO disclosed
EP-0852340-A1 SPACER FOR LIQUID CRYSTAL DISPLAY PANELS, METHOD OF MANUFACTURING THE SAME, AND LIQUID CRYSTAL DISPLAY PANEL NIPPON SHOKUBAI KABUSHIKI KAISHA (JP) 1998-07-08 EP disclosed
EP-0363584-B1 Silylation method GEN ELECTRIC (US) 1994-09-14 EP disclosed
EP-0284873-B1 SILYLATION METHOD GENERAL ELECTRIC COMPANY (US) 1993-09-01 EP disclosed
US-5082959-A Oxidation of alkyl groups substituted on a trialkylsilyl-substituted aromatic ring using oxygen gas and a cobalt and/or manganese compound and a bromide as catalyts AMOCO CORPORATION (US) 1992-01-21 US disclosed
EP-0363584-A2 Silylation method GENERAL ELECTRIC COMPANY (US) 1990-04-18 EP disclosed
US-4918197-A CATALYTIC REACTION BETWEEN AROMATIC ACYLHALIDE AND HALOGENATED POLYSILANE GENERAL ELECTRIC COMPANY (US) 1990-04-17 US disclosed
EP-0284873-A2 Silylation method GENERAL ELECTRIC COMPANY (US) 1988-10-05 EP disclosed
US-4709054-A REACTION OF AROMATIC ACYL HALIDE AND HALOGENATED POLYSILANE, TRANSITION METAL CATALYST GENERAL ELECTRIC COMPANY (US) 1987-11-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230312616-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CFTR, SCNN1G, SCNN1B ACHE 4850/4885TDP1 4655/4885ALDH1A1 3972/4885
US-20250171469-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CFTR, SCNN1G, SCNN1B ACHE 4850/4885TDP1 4655/4885ALDH1A1 3972/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.