Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.47 |
| ▸ | HTR3B | O95264 | 5/20 | 0.47 |
| ▸ | HTR3A | P46098 | 5/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19380551 | 0.81 | HTR3E (0.40) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL21917529 | 0.71 | PTAFR (0.37) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL19036185 | 0.71 | MAPK8 (0.46) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL17965501 | 0.70 | KDM4E (0.44) | ALDH1A1GLAMAPTHPGDACHE | |
| SCHEMBL30578099 | 0.69 | MAPK8 (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL1772018 | 0.69 | MAPK8 (0.40) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL31746758 | 0.69 | MAPK8 (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL120846 | 0.69 | MAPK8 (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL13131265 | 0.69 | PTPN2 (0.59) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL27265682 | 0.69 | HTR3E (0.43) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054498-B1 | BISIMIDAZODIAZOCINES | IDEMITSU KOSAN CO (JP) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016125110-A1 | BISIMIDAZOLODIAZOCINES | IDEMITSU KOSAN CO., LTD. (JP) | 2016-08-11 | — | — | WO | disclosed |
| EP-3054498-A1 | Bisimidazodiazocines | Idemitsu Kosan Co., Ltd. (JP) | 2016-08-10 | — | — | EP | disclosed |