Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KLK7 | P49862 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4162497 | 0.84 | HTT (0.65) | HTTTDP1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL17993528 | 0.83 | LOXL2 (0.56) | TDP1RAB9AKMT2ALMNANPC1 | |
| SCHEMBL169824 | 0.83 | TDP1 (0.76) | HTTTDP1RAB9AKMT2ACRHBP | |
| SCHEMBL437370 | 0.82 | MAPK8 (0.57) | HTTRAB9AKMT2ACRHBPCRHR2 | |
| SCHEMBL7905681 | 0.81 | HTT (0.71) | HTTTDP1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL17993526 | 0.81 | KMT2A (0.64) | HTTKMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL14817500 | 0.80 | RAB9A (0.61) | HTTTDP1RAB9AKMT2ACRHBP | |
| SCHEMBL9664904 | 0.80 | HTT (0.59) | HTTTDP1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL2494898 | 0.80 | HTT (0.73) | HTTTDP1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL4928502 | 0.80 | HTT (0.73) | HTTTDP1RAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426108-B1 | Processes and intermediates for preparing fused heterocyclic kinase inhibitors | METHYLGENE INC (CA) | 2016-08-10 | — | — | EP | disclosed |