Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17967300 | 0.92 | KMT2A (0.41) | ALDH1A1HPGDKMT2ALMNAUSP2 | |
| SCHEMBL2601040 | 0.85 | ALDH1A1 (0.45) | ALDH1A1HPGDKMT2ALMNAUSP2 | |
| SCHEMBL19334681 | 0.82 | LMNA (0.44) | ALDH1A1HPGDKMT2ALMNAUSP2 | |
| SCHEMBL19245942 | 0.81 | BRD4 (0.39) | ALDH1A1HPGDKMT2ALMNANR4A2 | |
| SCHEMBL16239239 | 0.80 | RAB9A (0.41) | ALDH1A1HPGDKMT2ALMNANR4A2 | |
| SCHEMBL15064604 | 0.80 | BRD4 (0.38) | ALDH1A1HPGDKMT2ALMNANR4A2 | |
| SCHEMBL2601039 | 0.78 | ALDH1A1 (0.44) | ALDH1A1HPGDKMT2ALMNAUSP2 | |
| SCHEMBL19755582 | 0.78 | BRD4 (0.37) | ALDH1A1HPGDKMT2ALMNANR4A2 | |
| SCHEMBL16447915 | 0.78 | BRD4 (0.37) | ALDH1A1HPGDKMT2ALMNANR4A2 | |
| SCHEMBL12993194 | 0.77 | HPGD (0.44) | ALDH1A1HPGDKMT2ALMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10730888-B2 | Process for the preparation of dolutegravir | MYLAN LABORATORIES LIMITED (IN) | 2020-08-04 | — | — | US | disclosed |
| US-10730888-B2 | Process for the preparation of dolutegravir | MYLAN LABORATORIES LIMITED (IN) | 2020-08-04 | — | — | US | disclosed |
| CN-107531614-B | Preparation method of delogevir | 迈兰实验室有限公司 | 2020-04-10 | — | — | CN | disclosed |
| US-20180244693-A1 | Process for the preparation of dolutegravir | Mylan Laboratories Ltd. (IN) | 2018-08-30 | — | — | US | disclosed |
| WO-2016125192-A2 | PROCESS FOR THE PREPARATION OF DOLUTEGRAVIR | MYLAN LABORATORIES LIMITED (IN) | 2016-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10730888-B2 | Process for the preparation of dolutegravir | SAMHD1, TYMP, DUT | ALDH1A1 1421/4885HPGD 1012/4885KMT2A 2845/4885 |
| US-20180244693-A1 | Process for the preparation of dolutegravir | SAMHD1, TYMP, DUT | ALDH1A1 1421/4885HPGD 1012/4885KMT2A 2845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.