Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 2/20 | 0.51 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 9/20 | 0.50 |
| ▸ | MAOB | P27338 | 9/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 7/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.50 |
| ▸ | ACHE | P22303 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | RORA | P35398 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.49 |
| ▸ | RORB | Q92753 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22298166 | 0.84 | PGR (0.49) | FABP4FABP5MAOAMAOBGRIN1 | |
| SCHEMBL4552481 | 0.81 | FABP4 (0.68) | FABP4FABP5MAOAMAOBGRIN1 | |
| SCHEMBL4552166 | 0.81 | FABP4 (0.64) | FABP4FABP5MAOAMAOBGRIN1 | |
| SCHEMBL4729150 | 0.81 | FABP4 (0.51) | FABP4FABP5MAOAMAOBGRIN1 | |
| SCHEMBL5181736 | 0.79 | MAOA (0.69) | FABP4FABP5MAOAMAOBGRIN1 | |
| SCHEMBL6338101 | 0.79 | MAOA (0.69) | FABP4FABP5MAOAMAOBGRIN1 | |
| SCHEMBL5658338 | 0.79 | MAOA (0.69) | FABP4FABP5MAOAMAOBGRIN1 | |
| SCHEMBL10063551 | 0.79 | MAOA (0.69) | FABP4FABP5MAOAMAOBGRIN1 | |
| SCHEMBL16577620 | 0.78 | TDP1 (0.66) | PGRRORARORCRORBALDH1A1 | |
| SCHEMBL1335135 | 0.78 | PGR (0.73) | FABP4FABP5MAOAMAOBGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160229847-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER (US) | 2016-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229847-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | BACE1, BACE2, PSEN2 | FABP4 4159/4885FABP5 3267/4885MAOA 1066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.