SCHEMBL1801901

SCHEMBL1801901

C=C(C)C(=O)SCc1cccc(CSC(=O)C(=C)C)c1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC11A2 P49281 1/20 0.47
TAAR1 Q96RJ0 2/20 0.41
NOS1 P29475 2/20 0.41
IDO1 P14902 4/20 0.38
CYP1A2 P05177 1/20 0.37
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CYP2D6 P10635 1/20 0.34
NOS3 P29474 1/20 0.34
NOS2 P35228 1/20 0.34
TDP1 Q9NUW8 2/20 0.34
GAA P10253 1/20 0.34
EPHX1 P07099 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL331133 0.87 IDO1 (0.47) TAAR1NOS1IDO1NOS3NOS2
SCHEMBL26192576 0.86 SLC11A2 (0.36) SLC11A2TAAR1NOS1IDO1CYP1A2
SCHEMBL1803553 0.85 CYP2C19 (0.40) SLC11A2TAAR1CYP1A2SMN1; SMN2CYP2D6
SCHEMBL713087 0.84 NOS1 (0.41) TAAR1NOS1IDO1NOS3NOS2
SCHEMBL1802036 0.77 ALDH1A1 (0.35) TAAR1IDO1CYP1A2HTTSMN1; SMN2
SCHEMBL27472188 0.76 NOS1 (0.31) TAAR1NOS1IDO1NOS3NOS2
SCHEMBL26192578 0.75 ACACB (0.38) SMN1; SMN2
SCHEMBL1412747 0.74 ALDH1A1 (0.50) NOS1IDO1SMN1; SMN2
SCHEMBL12990577 0.74 TDP1 (0.39) TAAR1CYP1A2TDP1
SCHEMBL28163265 0.73 SLC11A2 (0.46) SLC11A2TAAR1NOS1IDO1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1813639-B1 METAL-CONTAINING COMPOUND AND USE THEREOF MITSUI CHEMICALS INC (JP) 2014-03-12 EP disclosed
US-7951968-B2 Metal-containing compound and use thereof MITSUI CHEMICALS, INC. (JP) 2011-05-31 US disclosed
US-20100261866-A1 METAL-CONTAINING COMPOUND AND USE THEREOF MITSUI CHEMICALS, INC. (JP) 2010-10-14 US disclosed
US-7772348-B2 optical resin, transparent, plastic lenses, high refractive index, heat resistance, strength; polythioether-polyene polymers; resin obtained by polymerization of metal-thiol compound; polythiourethanes, polythioether reacted with triallyl isocyanurate MITSUI CHEMICALS, INC. (JP) 2010-08-10 US disclosed
US-20080027198-A1 Metal-Containing Compound and Use Thereof MITSUI CHEMICALS, INC. (JP) 2008-01-31 US disclosed
EP-1813639-A1 METAL-CONTAINING COMPOUND AND USE THEREOF Mitsui Chemicals, Inc. (JP) 2007-08-01 EP disclosed
EP-1138670-B1 Polythiol, polymerizable composition, resin and lens, and process for preparing thiol compound MITSUI CHEMICALS INC (JP) 2005-05-25 EP disclosed
US-6770735-B2 ORGANIC SULFIDES SUCH AS 1,1,3,3-TETRAKIS(MERCAPTOMETHYLTHIO) PROPANE, USED TO FORM RESINS HAVING HIGH REFRACTIVE INDEX, IMPACT STRENGTH AND HEAT REISTANCE, FOR USE AS LENSES, PRISMS OR OPTICAL FIBER AND FILTERS MITSUI CHEMICALS, INC. (JP) 2004-08-03 US disclosed
US-6770734-B2 POLYMERIZABLE TO MAKE POLYTHIOURETHANES; LENSES WITH A HIGH REFRACTIVE INDEX MITSUI CHEMICALS, INC. (JP) 2004-08-03 US disclosed
US-20030199668-A1 Process for preparing a thiol compound MITSUI CHEMICALS, INC. (JP) 2003-10-23 US disclosed
US-20030149230-A1 Polythiol compound MITSUI CHEMICALS, INC. (JP) 2003-08-07 US disclosed
US-6596841-B2 For producing resin which is used for optical material such as a plastic lens, a prism, an optical fiber, a substrate for an information recording medium, a filter and a light emitting diodes; refractive index MITSUI CHEMICALS, INC. (JP) 2003-07-22 US disclosed
US-20020022713-A1 Polythiol, polymerizable composition, resin and lens, and process for preparing thiol compound MITSUI CHEMICALS, INC. (JP) 2002-02-21 US disclosed
EP-1138670-A1 Polythiol, polymerizable composition, resin and lens, and process for preparing thiol compound Mitsui Chemicals, Inc. (JP) 2001-10-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100261866-A1 METAL-CONTAINING COMPOUND AND USE THEREOF HSPH1, HSPA4L, PTCD3 SLC11A2 1237/4885TAAR1 3759/4885NOS1 1513/4885
US-20080027198-A1 Metal-Containing Compound and Use Thereof HSPH1, HSPA4L, PTCD3 SLC11A2 1237/4885TAAR1 3759/4885NOS1 1513/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.