Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 8/20 | 0.77 |
| ▸ | KIF11 | P52732 | 2/20 | 0.63 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | TDO2 | P48775 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | GABRP | O00591 | 1/20 | 0.56 |
| ▸ | GABRD | O14764 | 1/20 | 0.56 |
| ▸ | IKBKB | O14920 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | TOP1 | P11387 | 1/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.56 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29985895 | 0.87 | CHUK (1.00) | CHUKKIF11ACHETDO2KDM4E | |
| SCHEMBL14253012 | 0.87 | CHUK (1.00) | CHUKKIF11ACHETDO2KDM4E | |
| SCHEMBL1517851 | 0.82 | KIF11 (0.61) | CHUKKIF11ACHEKDM4EALDH1A1 | |
| SCHEMBL10134607 | 0.82 | PARP1 (0.63) | CHUKKIF11ACHEKDM4ECCNB2 | |
| SCHEMBL29507671 | 0.82 | KIF11 (0.61) | CHUKKIF11ACHEKDM4EALDH1A1 | |
| SCHEMBL12396541 | 0.82 | CHUK (0.78) | CHUKKIF11ACHETDO2KDM4E | |
| SCHEMBL30322777 | 0.82 | CHUK (0.78) | CHUKKIF11ACHETDO2KDM4E | |
| SCHEMBL4822655 | 0.78 | KIF11 (0.58) | CHUKKIF11TDO2KDM4EGABRP | |
| SCHEMBL2768542 | 0.78 | CHUK (0.77) | CHUKKIF11TDO2KDM4EGABRP | |
| SCHEMBL2770395 | 0.78 | CHUK (0.77) | CHUKKIF11TDO2KDM4EGABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951801-B2 | For therapy of inflammatory disease and cancer | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| US-7951801-B2 | For therapy of inflammatory disease and cancer | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| US-7951801-B2 | For therapy of inflammatory disease and cancer | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| EP-2206713-A1 | Beta-carbolines useful for treating inflammatory disease | Millennium Pharmaceuticals, Inc. (US) | 2010-07-14 | — | — | EP | disclosed |
| EP-2206713-A1 | Beta-carbolines useful for treating inflammatory disease | Millennium Pharmaceuticals, Inc. (US) | 2010-07-14 | — | — | EP | disclosed |
| US-7727985-B2 | Beta-carbolines useful for treating inflammatory disease | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-7727985-B2 | Beta-carbolines useful for treating inflammatory disease | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-7727985-B2 | Beta-carbolines useful for treating inflammatory disease | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| EP-1268477-B1 | SUBSTITUTED BETA-CARBOLINES WITH IKB-KINASE INHIBITING ACTIVITY | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-04-21 | — | — | EP | disclosed |
| US-20100093713-A1 | BETA-CARBOLINES USEFUL FOR TREATING INFLAMMATORY DISEASE | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-04-15 | — | — | US | disclosed |
| US-20050239781-A1 | Beta-carbolines useful for treating inflammatory disease | MILLENNIUM PHARMACEUTICALS, INC. | 2005-10-27 | — | — | US | disclosed |
| US-20040235839-A1 | Beta-carbolines useful for treating inflammatory disease | MILLENNIUM PHARMACEUTICALS, INC. | 2004-11-25 | — | — | US | disclosed |
| WO-2004092167-A1 | BETA-CARBOLINES USEFUL FOR TREATING INFLAMMATORY DISEASE | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-10-28 | — | — | WO | disclosed |
| US-20040110759-A1 | Substituted beta carbolines | AVENTIS PHARMA DEUTSCHLAND GMBH | 2004-06-10 | — | — | US | disclosed |
| US-6627637-B2 | I kappa B kinase inhibitors for treating various disorders including arthritis | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-09-30 | — | — | US | disclosed |
| EP-1268477-A1 | SUBSTITUTED BETA-CARBOLINES WITH IKB-KINASE INHIBITING ACTIVITY | Aventis Pharma Deutschland GmbH (DE) | 2003-01-02 | — | — | EP | disclosed |
| US-20020099068-A1 | Substituted beta carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2002-07-25 | — | — | US | disclosed |
| EP-1209158-A1 | Substituted beta-carbolines | Aventis Pharma Deutschland GmbH (DE) | 2002-05-29 | — | — | EP | disclosed |
| WO-2001068648-A1 | SUBSTITUTED BETA-CARBOLINES WITH IKB-KINASE INHIBITING ACTIVITY | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-09-20 | — | — | WO | disclosed |
| EP-1134221-A1 | Substituted beta-carbolines as lkB kinase inhibitors | Aventis Pharma Deutschland GmbH (DE) | 2001-09-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110759-A1 | Substituted beta carbolines | CSNK1A1, CSNK2A1, CSNK2B | CHUK 52/4885KIF11 3229/4885ACHE 904/4885 |
| US-20050239781-A1 | Beta-carbolines useful for treating inflammatory disease | IL1B, IL1A, ADRA2B | CHUK 439/4885KIF11 3951/4885ACHE 1010/4885 |
| US-20040235839-A1 | Beta-carbolines useful for treating inflammatory disease | NFKBIA, IRAK2, IRAK1 | CHUK 6/4885KIF11 3691/4885ACHE 2470/4885 |
| US-20100093713-A1 | BETA-CARBOLINES USEFUL FOR TREATING INFLAMMATORY DISEASE | NFKBIA, NFKB2, IKBKG | CHUK 8/4885KIF11 3667/4885ACHE 2175/4885 |
| US-20020099068-A1 | Substituted beta carbolines | CSNK1A1, CSNK2A1, CSNK2B | CHUK 52/4885KIF11 3229/4885ACHE 904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.