Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGAV | P06756 | 1/20 | 0.38 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10519057 | 1.00 | ELANE (0.42) | ELANEDPP4ARPOLBSPHK1 | |
| SCHEMBL4629178 | 0.87 | ALDH1A1 (0.48) | LMNAALDH1A1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL4629180 | 0.87 | ALDH1A1 (0.48) | LMNAALDH1A1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL17923185 | 0.83 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2CHRM2CHRM1CHRM3 | |
| SCHEMBL18040347 | 0.83 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2CHRM2CHRM1CHRM3 | |
| SCHEMBL26062664 | 0.81 | LTA4H (0.46) | LMNAALDH1A1ITGB3ITGB1ITGAV | |
| SCHEMBL15804626 | 0.81 | LMNA (0.40) | LMNASMN1; SMN2CHRM2CHRM1CHRM3 | |
| SCHEMBL31696763 | 0.81 | LTA4H (0.46) | LMNAALDH1A1ITGB3ITGB1ITGAV | |
| SCHEMBL3825928 | 0.80 | MAPT (0.40) | LMNACHRM2CHRM1CHRM3KEAP1 | |
| SCHEMBL15804629 | 0.79 | LMNA (0.39) | DPP4LMNAALDH1A1SMN1; SMN2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315767-B1 | PYRIDINO-PYRIDINONE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2013-09-04 | — | — | EP | disclosed |
| US-8436011-B2 | Pyridinopyridinone derivatives, preparation thereof and therapeutic use thereof | SANOFI (FR) | 2013-05-07 | — | — | US | disclosed |
| US-20110124643-A1 | PYRIDINOPYRIDINONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-05-26 | — | — | US | disclosed |
| EP-2315767-A2 | PYRIDINO-PYRIDINONE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2011-05-04 | — | — | EP | disclosed |
| WO-2010004197-A2 | PYRIDINO-PYRIDINONE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124643-A1 | PYRIDINOPYRIDINONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | FLT3, PDGFRB, PDGFRA | ELANE 3510/4885DPP4 1518/4885AR 3493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.